HitPredict

Interactor 1: CNTFR (P26992)
Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)
Gene: CNTFR

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 304
+	Hs
		500953 GHR_HUMAN (110-300): 2.28e-42: 158: 18.54		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		548629 PRLR_HUMAN (106-324): 1.04e-51: 183: 21.68		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		645942 CNTFR_HUMAN (1-356): 8.9e-69: 222: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924809 CSF3R_HUMAN (4-342): 2.01e-60: 210: 18.87		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		770716 CSF3R_MOUSE (2-346): 2.16e-57: 202: 19.37		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		560471 PRLR_HUMAN (106-324): 1.04e-51: 183: 21.68		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		557612 CNTFR_HUMAN (1-356): 8.9e-69: 222: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		500944 GHR_HUMAN (110-300): 2.28e-42: 158: 18.54		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		500956 GHR_HUMAN (110-300): 2.28e-42: 158: 18.54		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		500941 GHR_HUMAN (110-300): 2.28e-42: 158: 18.54		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		235248 NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31		CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12
+	Hs
		208961 NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		235234 NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		235243 NPHN_HUMAN (28-330): 4.05e-39: 150: 19.31		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Mm
		817304 LEPR_MOUSE (114-301): 3.71e-16: 82.2: 17.96		PLCG1_MOUSE (2-302): 1.1e-26: 112: 15.43
+	Hs
		580942 UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		817315 LEPR_HUMAN (190-301): 5.62e-15: 78.8: 23.68		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		674385 UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		963044 UFO_MOUSE (4-342): 1.19e-12: 71.4: 16.18		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		208998 UFO_HUMAN (1-342): 1.57e-13: 74.1: 15.64		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00