HitPredict

Interactor 1: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Interactor 2: GDF5 (P43026)
Growth/differentiation factor 5 (GDF-5) (Bone morphogenetic protein 14) (BMP-14) (Cartilage-derived morphogenetic protein 1) (CDMP-1) (Lipopolysaccharide-associated protein 4) (LAP-4) (LPS-associated protein 4) (Radotermin)
Gene: GDF5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8702914
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Activin_recp~TGF_beta
Common GO terms	GO:0005886 - plasma membrane GO:0030509 - BMP signaling pathway GO:0060391 - positive regulation of SMAD protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 513 Hs			1 501
+	Hs
		792920 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		GDF5_HUMAN (1-501): 0: 605: 100.00
+	Hs
		520099 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		BMP4_HUMAN (108-501): 3.13e-115: 347: 27.64
+	Hs
		574181 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		BMP7_HUMAN (109-500): 1.76e-108: 331: 24.59
+	Hs
		520070 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		BMP2_HUMAN (127-501): 2.08e-107: 327: 29.59
+	Hs
		602925 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		BMP6_HUMAN (94-500): 1.53e-103: 321: 25.24
+	Hs
		574203 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		BMP7_HUMAN (109-500): 1.76e-108: 331: 24.59
+	Hs
		520077 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		BMP2_HUMAN (127-501): 2.08e-107: 327: 29.59
+	Hs
		602931 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		BMP6_HUMAN (94-500): 1.53e-103: 321: 25.24
+	Hs
		312997 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		BMP10_HUMAN (131-501): 1.4e-90: 284: 26.95
+	Mm
		646088 AVR2A_MOUSE (1-513): 1.26e-154: 452: 99.61		INHBA_MOUSE (99-500): 1.2e-87: 277: 17.73
+	Hs
		646080 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		GDF2_HUMAN (101-501): 9.09e-86: 272: 24.31
+	Hs
		439881 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		INHBA_HUMAN (99-500): 2.68e-85: 271: 18.55
+	Hs
		313007 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		BMP10_HUMAN (131-501): 1.4e-90: 284: 26.95
+	Hs
		439886 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		INHBA_HUMAN (99-500): 2.68e-85: 271: 18.55
+	Hs
		59851 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		A4D1W7_HUMAN (99-500): 2.68e-85: 271: 18.55
+	Hs
		451817 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		INHBB_HUMAN (127-500): 2.38e-69: 229: 20.46
+	Hs
		646064 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		NODAL_HUMAN (159-500): 3.08e-68: 224: 23.58
+	Hs
		155757 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		GDF8_HUMAN (116-500): 7.92e-76: 244: 19.69
+	Hs
		451820 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		INHBB_HUMAN (127-500): 2.38e-69: 229: 20.46
+	Hs
		312855 AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12		GDF11_HUMAN (132-500): 3.24e-65: 218: 19.15