HitPredict

Interactor 1: RHG32 (A7KAX9)
Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)
Gene: ARHGAP32

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	33961781, 36931259, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007264 - small GTPase-mediated signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2087 Hs			1 245
+	Hs
		64684 RHG32_HUMAN (1-2087): 0: 1424: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		64689 RHG32_HUMAN (1-2087): 0: 1424: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		64662 RHG32_HUMAN (1-2087): 0: 1424: 100.00		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		64663 RHG32_HUMAN (1-2087): 0: 1424: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		64697 RHG32_HUMAN (1-2087): 0: 1424: 100.00		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		64683 RHG32_HUMAN (1-2087): 0: 1424: 100.00		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Mm
		910284 RHG33_MOUSE (73-1289): 3.48e-114: 398: 30.65		1433E_MOUSE (2-243): 1.31e-144: 406: 63.53
+	Mm
		910285 SRGP3_MOUSE (294-924): 1.56e-75: 277: 18.36		1433E_MOUSE (2-243): 1.31e-144: 406: 63.53
+	Hs
		200215 SRGP3_HUMAN (294-939): 5.72e-78: 284: 17.36		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Mm
		910322 SRGP2_MOUSE (191-939): 8.66e-75: 274: 16.09		1433E_MOUSE (2-243): 1.31e-144: 406: 63.53
+	Hs
		253335 SRGP2_HUMAN (191-939): 6.03e-73: 268: 16.21		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		253315 SRGP2_HUMAN (191-939): 6.03e-73: 268: 16.21		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		253338 SRGP2_HUMAN (191-939): 6.03e-73: 268: 16.21		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		253321 SRGP2_HUMAN (191-939): 6.03e-73: 268: 16.21		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		646969 RHG21_HUMAN (88-1152): 8.55e-69: 260: 14.84		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		683416 RHG21_HUMAN (88-1152): 8.55e-69: 260: 14.84		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		253322 SRGP2_HUMAN (191-939): 6.03e-73: 268: 16.21		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		253342 SRGP2_HUMAN (191-939): 6.03e-73: 268: 16.21		1433F_HUMAN (2-242): 7.16e-106: 307: 71.43
+	Hs
		253334 SRGP2_HUMAN (191-939): 6.03e-73: 268: 16.21		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		684094 RHG21_HUMAN (88-1152): 8.55e-69: 260: 14.84		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85