HitPredict

Interactor 1: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Interactor 2: TSC2 (P49815)
Tuberin (Tuberous sclerosis 2 protein)
Gene: TSC2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.747

Property	Details
Experiments	20618440, 17353931, 33961781, 36931259, 15161933, 17470459, 28514442, 12438239
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1807
+	Hs
		835035 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		TSC2_HUMAN (1-1807): 0: 2708: 100.00
+	Hs
		909678 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74
+	Hs
		646999 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		RGPA1_HUMAN (1385-1780): 1.79e-109: 390: 20.74
+	Hs
		196427 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83
+	Hs
		196402 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83
+	Hs
		196429 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		SI1L1_HUMAN (1451-1805): 8.9e-92: 333: 22.83
+	Dm
		114606 1433E_DROME (2-242): 6.77e-143: 401: 65.02		M9PD17_DROME (1255-1756): 5.21e-86: 315: 31.22
+	Dm
		955043 1433E_DROME (2-242): 6.77e-143: 401: 65.02		Q9VW83_DROME (1255-1756): 5.71e-86: 315: 31.22
+	Mm
		926787 1433Z_MOUSE (1-245): 3.06e-142: 399: 80.00		Q3TQ10_MOUSE (1576-1807): 8.09e-98: 316: 77.69
+	Dm
		114591 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		M9PD17_DROME (1255-1756): 5.21e-86: 315: 31.22
+	Dm
		664663 1433Z_DROME (1-245): 3.68e-141: 397: 77.14		Q9VW83_DROME (1255-1756): 5.71e-86: 315: 31.22
+	Hs
		910116 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SI1L2_HUMAN (1459-1800): 2.08e-79: 293: 20.17
+	Hs
		230231 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33
+	Hs
		647347 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		SI1L2_HUMAN (1459-1800): 2.08e-79: 293: 20.17
+	Hs
		230206 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33
+	Hs
		230235 1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59		SI1L3_HUMAN (1459-1807): 3.43e-77: 286: 21.33
+	Hs
		647184 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		SIPA1_HUMAN (1258-1800): 6.13e-74: 271: 18.39
+	Hs
		812874 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RPGP1_HUMAN (1513-1765): 1.64e-69: 250: 24.23
+	Hs
		646716 1433T_HUMAN (1-245): 9.47e-142: 398: 100.00		RPGP1_HUMAN (1513-1765): 1.64e-69: 250: 24.23
+	Hs
		909669 1433E_HUMAN (2-243): 1.31e-144: 406: 63.53		RPGP2_HUMAN (1471-1758): 2.83e-66: 242: 22.03