HitPredict

Interactor 1: TNR5 (P27512)
Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CD antigen CD40)
Gene: Cd40

Interactor 2: TRAF6 (P70196)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 0.60 0.681

The method score is based on:

Property Details
Experiments 18635759, 10748240, 17878362, 8910514
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid, pull down
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0002637 - regulation of immunoglobulin production
GO:0032735 - positive regulation of interleukin-12 production
GO:0035631 - CD40 receptor complex
GO:0043123 - positive regulation of canonical NF-kappaB signal transduction
GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 289
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1 530
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024