HitPredict

Interactor 1: ARNT (P27540)
Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Class E basic helix-loop-helix protein 2) (bHLHe2) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1-beta) (HIF-1-beta) (HIF1-beta)
Gene: ARNT

Interactor 2: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	12024042
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HLH~PAS, PAS~PAS, PAS~PAS_11, PAS_11~PAS_11
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0090575 - RNA polymerase II transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 789 Hs			1 1441
+	Hs
		649131 ARNT_HUMAN (1-789): 0: 649: 100.00		NPAS4_HUMAN (27-841): 1.84e-138: 447: 14.66
+	Hs
		649084 ARNT_HUMAN (1-789): 0: 649: 100.00		SIM1_HUMAN (25-800): 1.46e-113: 378: 15.51
+	Mm
		864792 ARNT_MOUSE (1-789): 0: 637: 91.40		SIM1_MOUSE (25-800): 3.64e-112: 374: 15.40
+	Hs
		649150 ARNT_HUMAN (1-789): 0: 649: 100.00		EPAS1_HUMAN (15-890): 5.41e-104: 354: 13.27
+	Hs
		649123 ARNT_HUMAN (1-789): 0: 649: 100.00		HIF1A_HUMAN (8-798): 3.33e-103: 351: 13.33
+	Mm
		864794 ARNT_MOUSE (1-789): 0: 637: 91.40		HIF1A_MOUSE (8-756): 1.16e-106: 361: 12.99
+	Mm
		864790 ARNT_MOUSE (1-789): 0: 637: 91.40		EPAS1_MOUSE (15-890): 5.04e-96: 332: 13.94
+	Hs
		649132 ARNT_HUMAN (1-789): 0: 649: 100.00		NPAS3_HUMAN (23-852): 1.84e-87: 308: 13.03
+	Hs
		649106 ARNT_HUMAN (1-789): 0: 649: 100.00		SIM2_HUMAN (25-667): 4.72e-86: 297: 14.75
+	Mm
		101520 ARNT_MOUSE (1-789): 0: 637: 91.40		F8VQB2_MOUSE (23-687): 4.22e-87: 307: 15.14
+	Mm
		864793 ARNT_MOUSE (1-789): 0: 637: 91.40		SIM2_MOUSE (25-707): 6.09e-87: 300: 15.87
+	Mm
		674910 ARNT_MOUSE (1-789): 0: 637: 91.40		AHR_MOUSE (2-833): 2.52e-84: 297: 13.87
+	Hs
		649052 ARNT_HUMAN (1-789): 0: 649: 100.00		AHR_HUMAN (2-833): 8.86e-80: 284: 13.86
+	Hs
		181499 ARNT_HUMAN (1-789): 0: 649: 100.00		CLOCK_HUMAN (5-833): 1.42e-75: 271: 14.15
+	Hs
		649033 ARNT_HUMAN (1-789): 0: 649: 100.00		ARNT_HUMAN (1-642): 5.73e-69: 250: 16.45
+	Hs
		649148 ARNT_HUMAN (1-789): 0: 649: 100.00		NPAS1_HUMAN (23-506): 1.3e-68: 245: 15.11
+	Mm
		864789 ARNT_MOUSE (1-789): 0: 637: 91.40		NPAS1_MOUSE (23-551): 5.9e-71: 252: 15.56
+	Hs
		649117 ARNT_HUMAN (1-789): 0: 649: 100.00		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		649149 ARNT_HUMAN (1-789): 0: 649: 100.00		NPAS2_HUMAN (29-210): 2.08e-09: 64.3: 29.73
+	Hs
		69415 ARNT_HUMAN (1-789): 0: 649: 100.00		AHRR_HUMAN (29-186): 6.1e-09: 62.8: 31.10