HitPredict

Interactor 1: LEF1 (P27782)
Lymphoid enhancer-binding factor 1 (LEF-1)
Gene: LEF1

Interactor 2: CTNB1 (Q02248)
Catenin beta-1 (Beta-catenin)
Gene: Ctnnb1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.940

The method score is based on:

Property Details
Experiments 18202148, 24748645, 17445771, 17090604, 10085258, 16293619
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, isothermal titration calorimetry
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Arm~CTNNB1_binding, Arm~HMG_box
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001222 - transcription corepressor binding
GO:0001569 - branching involved in blood vessel morphogenesis
GO:0001649 - osteoblast differentiation
GO:0001944 - vasculature development
and 22 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 397
Mm

1 781
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+ Ce
+ Ce
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024