Protein: TPC
Mitochondrial thiamine pyrophosphate carrier (Mitochondrial thiamine pyrophosphate transporter) (MTPPT) (Mitochondrial uncoupling protein 1) (Solute carrier family 25 member 19)

Gene: TPC, SLC25A19
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q9HC21

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0009229 - thiamine diphosphate biosynthetic process
GO:0015234 - thiamine transmembrane transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1438544

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

5

High-throughput

0.618

High

1280513

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.536

High

1350894

HUMMR
Protein MGARP

1

10

High-throughput

0.536

High

166049

FFAR1
Free fatty acid receptor 1

1

17

High-throughput

0.489

High

182782

GP182
G-protein coupled receptor 182

1

20

High-throughput

0.489

High

260963

RAMP3
Receptor activity-modifying protein 3

1

5

High-throughput

0.489

High

268939

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

1

2

High-throughput

0.489

High

344494

STR3N
STARD3 N-terminal-like protein

1

1

High-throughput

0.489

High

469552

SYPH
Synaptophysin

1

2

High-throughput

0.489

High

488346

PPBI
Intestinal-type alkaline phosphatase

1

1

High-throughput

0.489

High

564931

ICAM2
Intercellular adhesion molecule 2

1

1

High-throughput

0.489

High

733079

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

3

High-throughput

0.489

High

749401

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

2

High-throughput

0.489

High

771238

APJ
Apelin receptor

1

13

High-throughput

0.489

High

845140

EAA3
Excitatory amino acid transporter 3

1

4

High-throughput

0.489

High

1034825

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

4

High-throughput

0.489

High

1057115

FMOD
Fibromodulin

1

2

High-throughput

0.489

High

1086114

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.489

High

1102961

ITAD
Integrin alpha-D

1

3

High-throughput

0.489

High

1159238

SGCA
Alpha-sarcoglycan

1

1

High-throughput

0.489

High

1287184

T150A
Transmembrane protein 150A

1

2

High-throughput

0.489

High

1324864

LRC25
Leucine-rich repeat-containing protein 25

1

6

High-throughput

0.489

High

1325925

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

4

High-throughput

0.489

High

1363146

CLC2B
C-type lectin domain family 2 member B

1

7

High-throughput

0.489

High

1399618

OPALI
Opalin

1

2

High-throughput

0.489

High

1433662

CST9L
Cystatin-9-like

1

6

High-throughput

0.489

High

1438439

SACA1
Sperm acrosome membrane-associated protein 1

1

2

High-throughput

0.489

High

1438538

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

2

High-throughput

0.489

High

1438539

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

1438541

CLC2D
C-type lectin domain family 2 member D

1

8

High-throughput

0.489

High

1438543

CLC4E
C-type lectin domain family 4 member E

1

7

High-throughput

0.489

High

1438546

PCDB3
Protocadherin beta-3

1

1

High-throughput

0.489

High

1438547

PCDBF
Protocadherin beta-15

1

1

High-throughput

0.489

High

1438548

GPR45
Probable G-protein coupled receptor 45

1

12

High-throughput

0.489

High

1438549

NPTN
Neuroplastin

1

8

High-throughput

0.489

High

223344

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

401514

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.479

High

589743

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

696560

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

783420

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.479

High

831460

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

905160

MECP2
Methyl-CpG-binding protein 2

1

6

High-throughput

0.479

High

971106

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

1162564

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.479

High

1397445

CI072
Guanine nucleotide exchange factor C9orf72

1

5

High-throughput

0.479

High

1403435

IMP2L
Mitochondrial inner membrane protease subunit 2

1

6

High-throughput

0.479

High

1429940

BRD8
Bromodomain-containing protein 8

1

9

High-throughput

0.479

High

1438535

DBLOH
Diablo IAP-binding mitochondrial protein

1

1

High-throughput

0.479

High

1438542

XPO7
Exportin-7

1

2

High-throughput

0.479

High

1359196

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1438545

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

0

High-throughput

0.458

High

430379

JUN
Transcription factor Jun

1

8

High-throughput

0.445

High

653580

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.445

High

1438537

ATD3A
ATPase family AAA domain-containing protein 3A

1

11

High-throughput

0.445

High

294354

CD123
Translation initiation factor eIF2 assembly protein

1

6

High-throughput

0.437

High

643081

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.437

High

769229

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

942897

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.437

High

1163873

DUS6
Dual specificity protein phosphatase 6

1

1

High-throughput

0.437

High

1178390

CL16A
Protein CLEC16A

1

3

High-throughput

0.437

High

1333339

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.437

High

1383249

CLUA1
Clusterin-associated protein 1

1

3

High-throughput

0.437

High

1433940

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.437

High

169146

ML12B
Myosin regulatory light chain 12B

1

3

High-throughput

0.407

High

573995

MYL6B
Myosin light chain 6B

1

3

High-throughput

0.407

High

1271273

SV2B
Synaptic vesicle glycoprotein 2B

1

15

High-throughput

0.407

High

1400777

MYCT
Proton myo-inositol cotransporter

1

3

High-throughput

0.407

High

231814

MFS11
UNC93-like protein MFSD11

1

0

High-throughput

0.279

Low

320506

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.279

Low

329980

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.279

Low

483396

CLCB
Clathrin light chain B

1

0

High-throughput

0.279

Low

1273210

CHSTF
Carbohydrate sulfotransferase 15

1

0

High-throughput

0.279

Low

1334652

RETR2
Reticulophagy regulator 2

1

0

High-throughput

0.279

Low

1352029

ACTT2
Actin-related protein T2

1

0

High-throughput

0.279

Low

1390885

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.279

Low

1436073

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.279

Low

1438540

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.279

Low

1438536

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1365290

SEPT8
Septin-8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025