HitPredict

Interactor 1: CALR (P27797)
Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)
Gene: CALR

Interactor 2: TMX1 (Q9H3N1)
Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein)
Gene: TMX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 417 Hs			1 280
+	Hs
		1296648 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		TMX1_HUMAN (1-280): 1.13e-79: 243: 100.00
+	Hs
		653695 CALR_HUMAN (18-417): 0: 519: 100.00		TMX3_HUMAN (6-270): 4.15e-49: 170: 15.94
+	Dm
		667040 CALR_DROME (4-406): 7.43e-167: 475: 66.58		PDIA6_DROME (6-275): 8.21e-60: 197: 17.51
+	Hs
		653711 CALR_HUMAN (18-417): 0: 519: 100.00		ERP44_HUMAN (1-161): 1.35e-38: 141: 23.12
+	Hs
		653597 CALR_HUMAN (18-417): 0: 519: 100.00		PDIA6_HUMAN (25-146): 1.28e-34: 131: 31.01
+	Dm
		667020 CALR_DROME (4-406): 7.43e-167: 475: 66.58		Q3YMU0_DROME (15-172): 3.17e-38: 142: 24.24
+	Hs
		1296643 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		ERP44_HUMAN (1-161): 1.35e-38: 141: 23.12
+	Hs
		1067796 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		PDIA6_HUMAN (25-146): 1.28e-34: 131: 31.01
+	Hs
		1055308 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		PDIA5_HUMAN (5-228): 1.07e-33: 129: 14.58
+	Hs
		1240407 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		TXND5_HUMAN (24-135): 1.06e-32: 126: 25.00
+	Hs
		531728 CALR_HUMAN (18-417): 0: 519: 100.00		PDIA4_HUMAN (119-266): 7.26e-15: 76.3: 9.68
+	Hs
		653650 CALR_HUMAN (18-417): 0: 519: 100.00		DJC10_HUMAN (64-264): 2.26e-14: 74.8: 10.95
+	Hs
		653491 CALR_HUMAN (18-417): 0: 519: 100.00		PDIA3_HUMAN (147-256): 2.92e-14: 74.4: 12.61
+	At
		137900 CALR1_ARATH (7-359): 4.51e-150: 433: 54.34		PDI21_ARATH (28-175): 5.22e-35: 131: 26.75
+	Hs
		531950 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		PDIA4_HUMAN (119-266): 7.26e-15: 76.3: 9.68
+	Hs
		1220455 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		DJC10_HUMAN (64-264): 2.26e-14: 74.8: 10.95
+	Hs
		671897 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		PDIA3_HUMAN (147-256): 2.92e-14: 74.4: 12.61
+	Dm
		667013 CALR_DROME (4-406): 7.43e-167: 475: 66.58		PDI_DROME (60-261): 1.05e-10: 63.6: 13.02
+	Hs
		423330 CALR3_HUMAN (1-362): 1.5e-165: 471: 51.38		PDIA1_HUMAN (66-256): 1.82e-10: 62.8: 10.68
+	Hs
		423150 CALX_HUMAN (20-416): 1.51e-145: 428: 34.39		PDIA1_HUMAN (66-256): 1.82e-10: 62.8: 10.68