Protein: PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 1 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Transmembrane protein 55B)

Gene: PP4P1, PIP4P1
Organism: Homo sapiens
Interactions: 104
UniProt ID: Q86T03

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane
GO:0006644 - phospholipid metabolic process
GO:0006991 - response to sterol depletion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1233314

LTOR1
Ragulator complex protein LAMTOR1

3

0

Small-scale

0.628

High

901907

RAB9A
Ras-related protein Rab-9A

3

0

High-throughput

0.613

High

1226402

TBC9B
TBC1 domain family member 9B

3

2

High-throughput

0.609

High

1185983

SOAT
Sodium-dependent organic anion transporter

2

1

High-throughput

0.606

High

1204199

RIPL1
RILP-like protein 1

2

1

High-throughput

0.606

High

1286686

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.586

High

1246476

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

2

0

High-throughput

0.585

High

1286709

HAUS7
HAUS augmin-like complex subunit 7

2

0

High-throughput

0.585

High

329461

EPN2
Epsin-2

2

0

High-throughput

0.580

High

938064

TPD52
Tumor protein D52

2

1

High-throughput

0.574

High

303046

DFFB
DNA fragmentation factor subunit beta

1

1

High-throughput

0.536

High

366287

FA10
Coagulation factor X

1

4

High-throughput

0.536

High

540531

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.536

High

861667

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

High-throughput

0.536

High

1286705

RB39B
Ras-related protein Rab-39B

1

1

High-throughput

0.536

High

1286712

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

3

High-throughput

0.536

High

1286718

ARL8B
ADP-ribosylation factor-like protein 8B

1

1

High-throughput

0.536

High

219193

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.513

High

220504

RNF13
E3 ubiquitin-protein ligase RNF13

1

0

High-throughput

0.513

High

243964

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

0

High-throughput

0.513

High

320463

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.513

High

845066

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.513

High

956362

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.513

High

1086026

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

1115780

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

1257728

VP13C
Intermembrane lipid transfer protein VPS13C

1

0

High-throughput

0.513

High

1286688

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.513

High

1286694

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

1286700

BORC5
BLOC-1-related complex subunit 5

1

0

High-throughput

0.513

High

1286702

BORC7
BLOC-1-related complex subunit 7

1

0

High-throughput

0.513

High

1286706

OPALI
Opalin

1

0

High-throughput

0.513

High

1286717

T106B
Transmembrane protein 106B

1

0

High-throughput

0.513

High

1286724

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.513

High

1286726

PIN4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

1

0

High-throughput

0.513

High

1286727

LTOR2
Ragulator complex protein LAMTOR2

1

0

High-throughput

0.513

High

862265

YAP1
Transcriptional coactivator YAP1

1

6

High-throughput

0.501

High

1091747

NFAC3
Nuclear factor of activated T-cells, cytoplasmic 3

1

2

High-throughput

0.500

High

1139750

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.493

High

1286699

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

215436

TPD54
Tumor protein D54

1

1

High-throughput

0.489

High

890133

EI2BB
Translation initiation factor eIF2B subunit beta

1

3

High-throughput

0.489

High

1037070

OC90
Otoconin-90

1

1

High-throughput

0.489

High

1095898

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

3

High-throughput

0.489

High

1286687

IT70B
Intraflagellar transport protein 70B

1

1

High-throughput

0.489

High

1286716

EI2BG
Translation initiation factor eIF2B subunit gamma

1

3

High-throughput

0.489

High

1055067

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

0

High-throughput

0.479

High

178801

SCAM1
Secretory carrier-associated membrane protein 1

1

1

High-throughput

0.479

High

374022

RASN
GTPase NRas

1

3

High-throughput

0.479

High

374717

RASH
GTPase HRas

1

2

High-throughput

0.479

High

375671

RASK
GTPase KRas

1

3

High-throughput

0.479

High

560439

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

562173

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

1031438

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1286691

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

1286710

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

4

Small-scale

0.479

High

1286723

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

1

1

High-throughput

0.479

High

178311

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

537431

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

851599

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

1248976

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1286701

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1286708

OR8B4
Olfactory receptor 8B4

1

0

High-throughput

0.458

High

870373

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

3

High-throughput

0.445

High

933525

S12A3
Solute carrier family 12 member 3

1

2

High-throughput

0.445

High

948869

CD81
CD81 antigen

1

3

High-throughput

0.445

High

1286696

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

1

1

High-throughput

0.445

High

1286711

S6A17
Sodium-dependent neutral amino acid transporter SLC6A17

1

3

High-throughput

0.445

High

293941

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

1254441

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

255103

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

388426

B3AT
Band 3 anion transport protein

1

0

High-throughput

0.426

High

834988

S19A1
Reduced folate transporter

1

0

High-throughput

0.426

High

1119186

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1286690

S15A4
Solute carrier family 15 member 4

1

0

High-throughput

0.426

High

1286692

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.426

High

1286707

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

1286721

VGLU2
Vesicular glutamate transporter 2

1

0

High-throughput

0.426

High

1286722

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.426

High

728

A0A087WXB0
Secretory carrier-associated membrane protein

1

1

High-throughput

0.407

High

653728

PROZ
Vitamin K-dependent protein Z

1

4

High-throughput

0.407

High

1242156

NPAL3
NIPA-like protein 3

1

1

High-throughput

0.407

High

1254222

TBCD9
TBC1 domain family member 9

1

2

High-throughput

0.407

High

1286695

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

1

High-throughput

0.407

High

1286698

GLMN
Glomulin

2

0

High-throughput

0.318

High

1286704

PKHB2
Pleckstrin homology domain-containing family B member 2

2

0

High-throughput

0.316

High

1224745

RN213
E3 ubiquitin-protein ligase RNF213

1

0

High-throughput

0.279

Low

1247601

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.279

Low

1286697

TM171
Transmembrane protein 171

1

0

High-throughput

0.279

Low

1286714

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.279

Low

1286715

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

0

High-throughput

0.279

Low

1286719

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

1

0

High-throughput

0.279

Low

1286720

ZNFX1
NFX1-type zinc finger-containing protein 1

1

0

High-throughput

0.279

Low

1286728

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

302068

SEGN
Secretagogin

1

0

High-throughput

0.269

Low

966546

1433G
14-3-3 protein gamma

1

0

High-throughput

0.268

Low

1286693

LMO3
LIM domain only protein 3

1

0

High-throughput

0.268

Low

258152

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.249

Low

1253614

DYH12
Dynein axonemal heavy chain 12

1

0

High-throughput

0.249

Low

1279046

RIC3
Protein RIC-3

1

0

High-throughput

0.249

Low

1286703

FAF2
FAS-associated factor 2

1

0

High-throughput

0.249

Low

1286725

G3BP2
Ras GTPase-activating protein-binding protein 2

1

0

High-throughput

0.249

Low

1286689

SVOP
Synaptic vesicle 2-related protein

1

0

High-throughput

0.232

Low

1286713

GCP60
Golgi resident protein GCP60

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025