HitPredict

Interactor 1: SFPQ (P23246)
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)
Gene: SFPQ

Interactor 2: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.990

The method score is based on:

Property Details
Experiments 12403470, 30021884, 31815296, 21819346, 37071682, 35575683, 39358380, 31839598, 39422127, 17452459, 17507659, 28514442, 30445466, 30725116, 24981860, 33961781, 34017080, 35271311, 35235311, 26414014 and 5 others

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Identification Methods two hybrid, proximity labelling technology, affinity chromatography technology, pull down, cross-linking study, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains NOPS~NOPS, NOPS~RRM_1, RRM_1~RRM_1
Common GO terms GO:0002218 - activation of innate immune response
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003723 - RNA binding
GO:0005634 - nucleus
and 11 others

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Homologous interactions 19

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 11Aug2025