HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: TGFR1 (P36897)
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Gene: TGFBR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15657037, 9435577
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0016020 - membrane GO:0051491 - positive regulation of filopodium assembly
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 503
+	Hs
		655244 P85A_HUMAN (1-724): 0: 596: 100.00		TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94
+	Hs
		129227 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		TGFR1_HUMAN (1-503): 6.66e-149: 437: 100.00
+	Hs
		129228 P85B_HUMAN (4-719): 6.38e-162: 486: 57.24		TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94
+	Hs
		740024 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94
+	Hs
		1044931 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		AVR2B_HUMAN (53-498): 2.08e-105: 325: 30.50
+	Hs
		1086131 P55G_HUMAN (271-723): 1.4e-104: 329: 72.31		AMHR2_HUMAN (205-499): 3.07e-44: 166: 33.87
+	Hs
		433275 YES_HUMAN (568-724): 2.15e-31: 131: 20.61		TGFR2_HUMAN (38-497): 1.43e-118: 361: 31.94