HitPredict

Interactor 1: BRAF (P28028)
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf)
Gene: BRAF

Interactor 2: 1433G (P61982)
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: Ywhag

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27034005
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~C1_1, 14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0098793 - presynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 751 Mm			1 247
+	Mm
		655938 BRAF_MOUSE (31-751): 0: 699: 100.00		1433E_MOUSE (1-244): 2.02e-141: 398: 63.53
+	Mm
		655947 BRAF_MOUSE (31-751): 0: 699: 100.00		1433F_MOUSE (1-246): 1.51e-136: 385: 86.99
+	Hs
		542849 BRAF_HUMAN (31-751): 0: 676: 90.90		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		542847 BRAF_HUMAN (31-751): 0: 676: 90.90		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		110869 H7C560_HUMAN (31-750): 0: 668: 90.62		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		542868 BRAF_HUMAN (31-751): 0: 676: 90.90		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Gg
		982833 BRAF_CHICK (37-751): 0: 657: 89.99		1433G_CHICK (1-247): 7.26e-140: 393: 99.60
+	Gg
		982837 BRAF_CHICK (37-751): 0: 657: 89.99		Q5ZKJ2_CHICK (1-247): 4.16e-134: 379: 87.45
+	Mm
		655943 BRAF_MOUSE (31-751): 0: 699: 100.00		1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59
+	Mm
		655981 BRAF_MOUSE (31-751): 0: 699: 100.00		1433B_MOUSE (2-247): 8.57e-109: 315: 75.81
+	Mm
		655946 BRAF_MOUSE (31-751): 0: 699: 100.00		1433T_MOUSE (2-245): 3e-105: 306: 70.73
+	Hs
		542827 BRAF_HUMAN (31-751): 0: 676: 90.90		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		542857 BRAF_HUMAN (31-751): 0: 676: 90.90		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		110870 H7C560_HUMAN (31-750): 0: 668: 90.62		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		542820 BRAF_HUMAN (31-751): 0: 676: 90.90		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Mm
		250867 BRAF_MOUSE (31-751): 0: 699: 100.00		1433S_MOUSE (2-236): 1.38e-95: 281: 65.96
+	Gg
		982838 BRAF_CHICK (37-751): 0: 657: 89.99		1433B_CHICK (2-247): 1.22e-109: 317: 76.21
+	Gg
		982836 BRAF_CHICK (37-751): 0: 657: 89.99		1433Z_CHICK (2-245): 4.61e-108: 313: 74.59
+	Hs
		542828 BRAF_HUMAN (31-751): 0: 676: 90.90		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Gg
		982840 BRAF_CHICK (37-751): 0: 657: 89.99		1433T_CHICK (2-245): 5.56e-106: 308: 71.14