HitPredict

Interactor 1: PSB9 (P28065)
Proteasome subunit beta type-9 (EC 3.4.25.1) (Low molecular mass protein 2) (Macropain chain 7) (Multicatalytic endopeptidase complex chain 7) (Proteasome chain 7) (Proteasome subunit beta-1i) (Really interesting new gene 12 protein)
Gene: PSMB9

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.903

Property	Details
Experiments	26186194, 28514442, 30833792, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA~Proteasome, AAA_lid_3~Proteasome
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 219 Hs			1 406
+	At
		1114627 PSA5B_ARATH (5-219): 2.01e-81: 244: 16.74		PRS4A_ARATH (19-396): 1.25e-158: 455: 47.62
+	At
		286460 PSA5A_ARATH (5-219): 9.89e-82: 244: 17.18		PRS4A_ARATH (19-396): 1.25e-158: 455: 47.62
+	At
		286458 PSA4A_ARATH (5-219): 6.17e-76: 230: 16.23		PRS4A_ARATH (19-396): 1.25e-158: 455: 47.62
+	At
		188699 PSA2A_ARATH (2-219): 9.84e-76: 229: 18.06		PRS4A_ARATH (19-396): 1.25e-158: 455: 47.62
+	Dm
		47601 A0AQH0_DROME (7-212): 3.3e-77: 233: 51.21		PRS4_DROME (4-396): 3.02e-138: 403: 45.04
+	Hs
		656194 PSA5_HUMAN (5-219): 2.62e-78: 236: 17.90		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		656193 PSA5_HUMAN (5-219): 2.62e-78: 236: 17.90		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		656104 PSB9_HUMAN (1-219): 4.78e-76: 229: 100.00		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		656167 PSA5_HUMAN (5-219): 2.62e-78: 236: 17.90		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Dm
		47615 A0AQH0_DROME (7-212): 3.3e-77: 233: 51.21		Q9V405_DROME (7-399): 9.79e-122: 360: 41.73
+	Hs
		656096 PSB9_HUMAN (1-219): 4.78e-76: 229: 100.00		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		656158 PSA5_HUMAN (5-219): 2.62e-78: 236: 17.90		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Dm
		47608 A0AQH0_DROME (7-212): 3.3e-77: 233: 51.21		Q7KMQ0_DROME (81-392): 1.77e-115: 345: 55.45
+	Hs
		656094 PSB9_HUMAN (1-219): 4.78e-76: 229: 100.00		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Sc
		703888 PSB1_YEAST (13-212): 1.62e-76: 231: 45.27		PRS7_YEAST (84-391): 1.53e-111: 336: 54.87
+	Hs
		656196 PSA5_HUMAN (5-219): 2.62e-78: 236: 17.90		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64
+	Dm
		47592 A0AQH0_DROME (7-212): 3.3e-77: 233: 51.21		PRS8_DROME (8-123): 6.29e-11: 65.5: 7.76
+	Dm
		47632 A0AQH0_DROME (7-212): 3.3e-77: 233: 51.21		Q9W414_DROME (8-101): 2.04e-10: 64: 10.64
+	Hs
		656106 PSB9_HUMAN (1-219): 4.78e-76: 229: 100.00		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64
+	Sc
		751176 PSB1_YEAST (13-212): 1.62e-76: 231: 45.27		PRS8_YEAST (8-110): 1.31e-09: 61.7: 7.77