HitPredict

Interactor 1: TEAD1 (P28347)
Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13)
Gene: TEAD1

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	26186194, 28514442, 25796446, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0035329 - hippo signaling GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 426 Hs			1 400
+	Mm
		671381 TEAD1_MOUSE (1-426): 0: 783: 99.30		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Mm
		1113240 Q3USK5_MOUSE (16-426): 0: 750: 91.74		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Hs
		1075220 TEAD4_HUMAN (1-426): 0: 725: 74.54		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Mm
		671378 TEAD1_MOUSE (1-426): 0: 783: 99.30		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Mm
		1143754 TEAD4_MOUSE (1-426): 0: 728: 74.07		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Hs
		658469 TEAD1_HUMAN (1-426): 0: 782: 100.00		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		1304848 TEAD3_HUMAN (12-426): 0: 691: 71.23		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Mm
		936316 TEAD3_MOUSE (1-426): 0: 684: 69.25		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Mm
		809073 TEAD4_MOUSE (1-426): 0: 728: 74.07		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Hs
		808635 TEAD4_HUMAN (1-426): 0: 725: 74.54		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		1075251 TEAD2_HUMAN (32-426): 0: 631: 67.07		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Hs
		808875 TEAD3_HUMAN (12-426): 0: 691: 71.23		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Mm
		809065 TEAD3_MOUSE (1-426): 0: 684: 69.25		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Mm
		817006 TEAD2_MOUSE (28-426): 0: 612: 65.06		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Hs
		808636 TEAD2_HUMAN (32-426): 0: 631: 67.07		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Mm
		809063 TEAD2_MOUSE (28-426): 0: 612: 65.06		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Hs
		808133 TEAD2_HUMAN (32-426): 0: 631: 67.07		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Dm
		671392 SCAL_DROME (2-426): 0: 569: 58.33		YAP1_DROME (17-223): 5.05e-46: 164: 22.80
+	Sc
		576198 TEC1_YEAST (35-251): 1.93e-29: 121: 21.88		RSP5_YEAST (60-356): 4.36e-33: 133: 13.24