HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: MP2K4 (P45985)
Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)
Gene: MAP2K4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12788955
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0007165 - signal transduction and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 399
+	Hs
		658893 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		KPCE_HUMAN (3-398): 4.27e-122: 372: 18.23
+	Mm
		554917 MK03_MOUSE (15-357): 1.88e-152: 435: 88.63		KPCE_MOUSE (6-398): 4.32e-122: 371: 17.73
+	Hs
		658839 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		MP2K3_HUMAN (22-387): 5.5e-121: 356: 46.72
+	Hs
		658863 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		MP2K6_HUMAN (69-386): 1.73e-121: 356: 54.72
+	Hs
		647503 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		MP2K3_HUMAN (22-387): 5.5e-121: 356: 46.72
+	Mm
		192876 O35558_MOUSE (10-285): 2.09e-147: 419: 94.57		KPCE_MOUSE (6-398): 4.32e-122: 371: 17.73
+	Hs
		153090 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		MP2K7_HUMAN (48-394): 7.51e-113: 338: 45.87
+	At
		1114822 MPK16_ARATH (1-356): 2.44e-147: 429: 45.43		CDPK8_ARATH (62-389): 3.75e-119: 357: 19.19
+	At
		1106388 MPK4_ARATH (14-357): 5.23e-151: 431: 51.01		M2K2_ARATH (56-383): 7.13e-102: 307: 31.05
+	At
		1259060 MPK16_ARATH (1-356): 2.44e-147: 429: 45.43		M2K2_ARATH (56-383): 7.13e-102: 307: 31.05
+	At
		1106354 MPK4_ARATH (14-357): 5.23e-151: 431: 51.01		M2K6_ARATH (72-381): 2e-100: 304: 33.33
+	Dm
		772963 ERKA_DROME (3-357): 2.75e-151: 432: 79.44		DSOR1_DROME (54-394): 4.56e-99: 302: 37.43
+	At
		1106332 MPK4_ARATH (14-357): 5.23e-151: 431: 51.01		M2K1_ARATH (45-383): 8.57e-100: 302: 30.29
+	Hs
		658818 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		MP2K2_HUMAN (100-393): 3.95e-62: 206: 37.24
+	Hs
		658897 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		MP2K1_HUMAN (100-393): 1.72e-60: 202: 36.20
+	Mm
		682463 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		MP2K1_MOUSE (100-393): 1.69e-60: 202: 36.20
+	Xl
		644534 MK01_XENLA (3-358): 2.26e-157: 447: 96.07		MP2K1_XENLA (52-393): 3.9e-59: 199: 33.25
+	Hs
		647488 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		MP2K2_HUMAN (100-393): 3.95e-62: 206: 37.24
+	Xl
		983287 Q6DFK6_XENLA (2-358): 2.06e-156: 444: 95.52		MP2K1_XENLA (52-393): 3.9e-59: 199: 33.25
+	Hs
		647547 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		MP2K1_HUMAN (100-393): 1.72e-60: 202: 36.20