Protein: PTPRJ
Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)

Gene: PTPRJ
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q12913

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001570 - vasculogenesis
GO:0001772 - immunological synapse
GO:0004725 - protein tyrosine phosphatase activity
GO:0005161 - platelet-derived growth factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1090052

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

3

17

Small-scale

0.836

High

691724

MK03
Mitogen-activated protein kinase 3

2

14

Small-scale

0.802

High

363202

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.799

High

472051

MET
Hepatocyte growth factor receptor

2

20

Small-scale

0.798

High

374554

RASH
GTPase HRas

2

18

High-throughput

0.793

High

484121

PGFRB
Platelet-derived growth factor receptor beta

2

20

Small-scale

0.789

High

375461

RASK
GTPase KRas

2

20

High-throughput

0.754

High

976234

RB11A
Ras-related protein Rab-11A

2

5

High-throughput

0.754

High

778058

VGFR2
Vascular endothelial growth factor receptor 2

1

20

Small-scale

0.730

High

609993

VGFR1
Vascular endothelial growth factor receptor 1

2

20

Small-scale

0.712

High

635714

RASA1
Ras GTPase-activating protein 1

1

13

High-throughput

0.698

High

1038282

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

4

High-throughput

0.698

High

1090079

PRD14
PR domain zinc finger protein 14

1

3

High-throughput

0.698

High

609666

LEG3
Galectin-3

4

20

High-throughput

0.691

High

703562

MK01
Mitogen-activated protein kinase 1

1

14

Small-scale

0.667

High

125434

LEG9
Galectin-9

3

20

High-throughput

0.667

High

254125

CTND1
Catenin delta-1

2

20

Small-scale

0.650

High

619042

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

1

Small-scale

0.647

High

140243

SDCB1
Syntenin-1

1

11

Small-scale

0.621

High

126569

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

241535

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.618

High

466226

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

581013

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601258

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

845618

MUC18
Cell surface glycoprotein MUC18

1

19

High-throughput

0.618

High

944984

RAB25
Ras-related protein Rab-25

1

5

High-throughput

0.618

High

953413

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955102

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

961995

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

977964

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

987595

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

988321

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1015394

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1090059

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1090064

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1090073

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1090080

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1090081

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

127320

LEG8
Galectin-8

3

20

High-throughput

0.609

High

480776

LEG1
Galectin-1

2

20

High-throughput

0.601

High

764704

CTNB1
Catenin beta-1

2

20

Small-scale

0.588

High

171234

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

9

High-throughput

0.575

High

193563

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

6

High-throughput

0.575

High

253343

JAK2
Tyrosine-protein kinase JAK2

1

20

High-throughput

0.575

High

410803

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.575

High

411833

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.575

High

439716

INSR
Insulin receptor

1

20

High-throughput

0.575

High

440049

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.575

High

532075

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.575

High

533845

GHR
Growth hormone receptor

1

19

High-throughput

0.575

High

619219

EPOR
Erythropoietin receptor

1

20

High-throughput

0.575

High

651301

CBL
E3 ubiquitin-protein ligase CBL

1

9

High-throughput

0.575

High

773345

TIE1
Tyrosine-protein kinase receptor Tie-1

1

20

High-throughput

0.575

High

834183

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.575

High

840877

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.575

High

871473

LEPR
Leptin receptor

1

19

High-throughput

0.575

High

1038431

TIE2
Angiopoietin-1 receptor

1

20

High-throughput

0.575

High

1060771

ACK1
Activated CDC42 kinase 1

1

20

High-throughput

0.575

High

1090087

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.575

High

189538

STX7
Syntaxin-7

2

4

High-throughput

0.571

High

1090055

GAB1
GRB2-associated-binding protein 1

2

10

Small-scale

0.571

High

220370

LAT
Linker for activation of T-cells family member 1

1

1

Small-scale

0.550

High

183457

CASC3
Protein CASC3

1

2

High-throughput

0.541

High

332631

LYPD3
Ly6/PLAUR domain-containing protein 3

1

1

High-throughput

0.541

High

482459

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.541

High

484835

HXC6
Homeobox protein Hox-C6

1

1

High-throughput

0.541

High

1090058

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

5

High-throughput

0.541

High

1090061

SFRP4
Secreted frizzled-related protein 4

1

1

High-throughput

0.541

High

1090066

TEFF1
Tomoregulin-1

1

7

High-throughput

0.541

High

1090069

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

4

High-throughput

0.541

High

1090078

HEMGN
Hemogen

1

1

High-throughput

0.541

High

164916

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

6

High-throughput

0.536

High

488279

CSF3
Granulocyte colony-stimulating factor

1

1

High-throughput

0.536

High

1090085

FBX2
F-box only protein 2

1

10

High-throughput

0.536

High

1025873

FANCC
Fanconi anemia group C protein

1

0

High-throughput

0.518

High

1090068

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.518

High

1090082

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.518

High

986017

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.515

High

1090071

CNKR1
Connector enhancer of kinase suppressor of ras 1

1

9

Small-scale

0.501

High

423965

CP17A
Steroid 17-alpha-hydroxylase/17,20 lyase

1

1

High-throughput

0.494

High

892100

KLK7
Kallikrein-7

1

10

High-throughput

0.494

High

977473

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

2

High-throughput

0.494

High

1090060

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

1

1

High-throughput

0.494

High

1090074

CANB2
Calcineurin subunit B type 2

1

1

High-throughput

0.494

High

1090077

TRMO
tRNA

1

1

High-throughput

0.494

High

1090086

KLK9
Kallikrein-9

1

9

High-throughput

0.494

High

218129

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

556048

CADH1
Cadherin-1

1

20

High-throughput

0.479

High

560384

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

577734

PLAK
Junction plakoglobin

1

20

Small-scale

0.479

High

868679

LEG7
Galectin-7

1

20

High-throughput

0.479

High

1031356

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.479

High

1090070

DDX17
Probable ATP-dependent RNA helicase DDX17

1

4

Small-scale

0.479

High

618248

CADH2
Cadherin-2

1

20

High-throughput

0.445

High

842645

WASP
Actin nucleation-promoting factor WAS

1

9

High-throughput

0.445

High

857092

NSF
Vesicle-fusing ATPase

1

11

High-throughput

0.445

High

878441

PAXI
Paxillin

1

12

High-throughput

0.445

High

1090054

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

9

High-throughput

0.445

High

1090056

SQSTM
Sequestosome-1

1

3

Small-scale

0.445

High

1090065

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

7

High-throughput

0.445

High

1090067

CTL1
Choline transporter-like protein 1

1

2

High-throughput

0.445

High

1090076

PKP4
Plakophilin-4

1

20

High-throughput

0.445

High

269762

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

9

High-throughput

0.437

High

1090062

RINT1
RAD50-interacting protein 1

1

1

High-throughput

0.437

High

1090063

RFIP1
Rab11 family-interacting protein 1

1

4

High-throughput

0.437

High

1090083

FBX6
F-box only protein 6

1

10

High-throughput

0.437

High

1090084

CS025
UPF0449 protein C19orf25

1

1

High-throughput

0.437

High

65410

MFS2B
Sphingosine-1-phosphate transporter MFSD2B

1

0

High-throughput

0.426

High

1090053

S13A2
Solute carrier family 13 member 2

1

0

High-throughput

0.426

High

1010028

DLK1
Protein delta homolog 1

1

11

High-throughput

0.407

High

1090075

MF14A
Hippocampus abundant transcript 1 protein

1

8

High-throughput

0.407

High

1090057

BAAT
Bile acid-CoA:amino acid N-acyltransferase

1

0

High-throughput

0.282

High

1090072

ESIP1
Epithelial-stromal interaction protein 1

1

0

High-throughput

0.282

High

1090088

ZN510
Zinc finger protein 510

1

0

High-throughput

0.282

High

341415

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.279

Low

50810

CA226
Uncharacterized protein C1orf226

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025