HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: DUS8 (Q13202)
Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5)
Gene: DUSP8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27432908
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DSPc~Pkinase, Pkinase~Rhodanese
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 625
+	Hs
		659043 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS16_HUMAN (1-625): 0: 547: 43.88
+	Hs
		658798 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS1_HUMAN (11-353): 9.13e-113: 344: 30.28
+	Hs
		647475 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS1_HUMAN (11-353): 9.13e-113: 344: 30.28
+	Hs
		658903 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS2_HUMAN (7-301): 4.88e-105: 322: 33.66
+	Hs
		658919 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS4_HUMAN (22-359): 4.07e-103: 320: 28.93
+	Mm
		926403 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS2_MOUSE (11-301): 5.87e-103: 316: 34.10
+	Hs
		658962 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS7_HUMAN (12-335): 1.03e-100: 314: 29.51
+	Mm
		926439 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS6_MOUSE (14-324): 6.85e-100: 311: 30.68
+	Rn
		926496 MK01_RAT (10-360): 4.96e-158: 449: 99.72		DUS6_RAT (14-324): 4.61e-99: 309: 30.11
+	Hs
		658961 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS6_HUMAN (14-324): 1.04e-98: 308: 30.40
+	Hs
		658960 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS5_HUMAN (11-376): 1.53e-98: 307: 25.45
+	Hs
		659102 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS10_HUMAN (6-302): 2.33e-88: 284: 34.40
+	Hs
		659034 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS9_HUMAN (12-340): 5.68e-83: 267: 27.03
+	Hs
		56510 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		PTPC1_HUMAN (120-583): 4.76e-66: 232: 14.18
+	Hs
		56508 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		PTPC1_HUMAN (120-583): 4.76e-66: 232: 14.18
+	Hs
		659006 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS19_HUMAN (106-313): 1.49e-61: 205: 26.54
+	Hs
		659008 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		STYX_HUMAN (161-311): 8.83e-56: 190: 33.74
+	Hs
		658858 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS3_HUMAN (147-307): 3.19e-56: 189: 27.65
+	Mm
		926438 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS3_MOUSE (147-300): 2.07e-54: 185: 28.22
+	Hs
		647521 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS3_HUMAN (147-307): 3.19e-56: 189: 27.65