HitPredict

Interactor 1: GRN (P28799)
Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]
Gene: GRN

Interactor 2: DJC10 (Q8IXB1)
DnaJ homolog subfamily C member 10 (EC 1.8.4.-) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr)
Gene: DNAJC10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	28514442, 33961781, 26370502
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0016020 - membrane GO:0051087 - protein-folding chaperone binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 793
+	Mm
		1322002 Q9D2V3_MOUSE (1-593): 0: 712: 75.04		DJC10_MOUSE (1-793): 0: 597: 90.29
+	Hs
		660499 GRN_HUMAN (1-593): 0: 726: 100.00		PDIA6_HUMAN (135-451): 3.77e-40: 155: 16.62
+	Hs
		531730 GRN_HUMAN (1-593): 0: 726: 100.00		PDIA4_HUMAN (153-643): 4.32e-35: 143: 13.67
+	Mm
		1265750 Q9D2V3_MOUSE (1-593): 0: 712: 75.04		PDIA6_MOUSE (117-451): 7.1e-40: 154: 17.36
+	Mm
		434694 Q9D2V3_MOUSE (1-593): 0: 712: 75.04		PDIA4_MOUSE (132-643): 5.32e-35: 143: 14.05
+	Hs
		660405 GRN_HUMAN (1-593): 0: 726: 100.00		PDIA3_HUMAN (235-674): 4.71e-27: 118: 13.24
+	Mm
		653447 Q9D2V3_MOUSE (1-593): 0: 712: 75.04		PDIA3_MOUSE (236-674): 4.27e-26: 115: 12.29
+	Hs
		423151 GRN_HUMAN (1-593): 0: 726: 100.00		PDIA1_HUMAN (86-231): 1.07e-10: 66.9: 18.00
+	Mm
		447646 Q9D2V3_MOUSE (1-593): 0: 712: 75.04		PDIA1_MOUSE (86-250): 3.44e-11: 68.5: 15.39
+	At
		794977 RD21A_ARATH (444-514): 6.21e-17: 85.5: 32.47		PDI11_ARATH (550-788): 7.45e-11: 67.3: 13.93
+	At
		1324487 RD21B_ARATH (128-193): 1.41e-16: 84.4: 34.67		PDI11_ARATH (550-788): 7.45e-11: 67.3: 13.93
+	At
		1339606 RD21C_ARATH (128-202): 2.14e-11: 68.2: 32.14		PDI11_ARATH (550-788): 7.45e-11: 67.3: 13.93