HitPredict

Interactor 1: AT2B4 (P23634)
Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
Gene: ATP2B4

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016525 - negative regulation of angiogenesis GO:1903078 - positive regulation of protein localization to plasma membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1241 Hs			1 976
+	Hs
		627267 AT2B1_HUMAN (1-1241): 0: 1149: 72.46		EPHA2_HUMAN (1-976): 0: 1124: 100.00
+	Hs
		420381 AT1A1_HUMAN (30-1060): 0: 759: 23.78		EPHA2_HUMAN (1-976): 0: 1124: 100.00
+	Hs
		627257 AT2B1_HUMAN (1-1241): 0: 1149: 72.46		FGFR3_HUMAN (381-889): 3.37e-136: 430: 24.65
+	Hs
		463336 AT2B4_HUMAN (1-1241): 0: 1304: 100.00		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Hs
		463324 AT2B1_HUMAN (1-1241): 0: 1149: 72.46		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91
+	Rn
		444692 AT1A1_RAT (30-1060): 0: 761: 23.60		INSR_RAT (371-873): 1.87e-134: 440: 29.49
+	Hs
		420307 AT1A1_HUMAN (30-1060): 0: 759: 23.78		LYN_HUMAN (607-879): 2.07e-64: 228: 42.91