HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0030027 - lamellipodium GO:0060326 - cell chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 192
+	Hs
		665201 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		545218 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		665332 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		925297 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		665208 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		665192 EPHA2_HUMAN (1-976): 0: 1141: 100.00		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		665194 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		545394 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		1072595 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		545285 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		436169 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		564420 EPHA2_HUMAN (1-976): 0: 1141: 100.00		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		892388 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		872418 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		951011 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		872419 EPHA5_HUMAN (11-976): 0: 1127: 51.34		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		900497 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436317 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		436223 EPHA5_HUMAN (11-976): 0: 1127: 51.34		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		564541 EPHA7_HUMAN (4-974): 0: 1128: 50.30		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49