Protein: MCM4
DNA replication licensing factor MCM4 (EC 3.6.4.12) (Cell division control protein 54)

Gene: MCM4
Organism: Saccharomyces cerevisiae S288C
Interactions: 155
UniProt ID: P30665

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0003678 - DNA helicase activity
GO:0003688 - DNA replication origin binding
GO:0003697 - single-stranded DNA binding
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

712951

MCM2
DNA replication licensing factor MCM2

24

20

Small-scale

0.991

High

721420

CDC45
Cell division control protein 45

27

16

Small-scale

0.990

High

721391

MCM6
DNA replication licensing factor MCM6

22

20

Small-scale

0.988

High

664418

MCM3
DNA replication licensing factor MCM3

21

20

Small-scale

0.987

High

721369

MCM7
DNA replication licensing factor MCM7

21

19

Small-scale

0.987

High

713243

MCM5
Minichromosome maintenance protein 5

18

19

Small-scale

0.983

High

721410

SLD5
DNA replication complex GINS protein SLD5

15

15

Small-scale

0.982

High

721436

PSF1
DNA replication complex GINS protein PSF1

15

12

Small-scale

0.981

High

721379

PSF2
DNA replication complex GINS protein PSF2

10

11

Small-scale

0.972

High

721429

PSF3
DNA replication complex GINS protein PSF3

10

10

Small-scale

0.969

High

721383

CDT1
Cell division cycle protein CDT1

6

4

Small-scale

0.943

High

642020

DPOE
DNA polymerase epsilon catalytic subunit A

4

13

Small-scale

0.878

High

721348

MCM4
DNA replication licensing factor MCM4

3

19

Small-scale

0.821

High

721405

CTF4
DNA polymerase alpha-binding protein

17

11

Small-scale

0.763

High

440912

CDC7
Cell division control protein 7

11

20

Small-scale

0.757

High

721353

MCM10
Minichromosome maintenance protein 10

10

14

Small-scale

0.757

High

561296

DPOLA
DNA polymerase alpha catalytic subunit A

9

13

Small-scale

0.751

High

721417

CSM3
Chromosome segregation in meiosis protein 3

9

4

Small-scale

0.748

High

677664

MRC1
Mediator of replication checkpoint protein 1

7

4

Small-scale

0.740

High

721393

SLD3
DNA replication regulator SLD3

4

4

Small-scale

0.688

High

721416

POB3
FACT complex subunit POB3

7

10

Small-scale

0.677

High

381930

H4
Histone H4

4

8

Small-scale

0.676

High

721400

ORC1
Origin recognition complex subunit 1

1

20

Small-scale

0.647

High

721397

TOF1
Topoisomerase 1-associated factor 1

3

9

Small-scale

0.640

High

721402

H3
Histone H3

3

20

Small-scale

0.640

High

721387

ORC5
Origin recognition complex subunit 5

1

7

Small-scale

0.618

High

721401

ORC4
Origin recognition complex subunit 4

1

20

Small-scale

0.618

High

721356

SPT16
FACT complex subunit SPT16

4

6

Small-scale

0.617

High

521113

PRI1
DNA primase small subunit

2

1

Small-scale

0.611

High

721362

SLD2
DNA replication regulator SLD2

2

4

Small-scale

0.595

High

448437

RAD52
DNA repair and recombination protein RAD52

2

2

Small-scale

0.586

High

675315

RAD51
DNA repair protein RAD51

2

1

Small-scale

0.586

High

721352

DBF4
DDK kinase regulatory subunit DBF4

2

4

Small-scale

0.585

High

381003

H2B1
Histone H2B.1

2

20

Small-scale

0.584

High

415208

TOP1
DNA topoisomerase 1

2

6

Small-scale

0.584

High

419379

H2A1
Histone H2A.1

2

20

Small-scale

0.584

High

419640

H2A2
Histone H2A.2

2

20

Small-scale

0.584

High

646330

RAD53
Serine/threonine-protein kinase RAD53

2

8

Small-scale

0.584

High

665172

DPB2
DNA polymerase epsilon subunit B

2

4

Small-scale

0.584

High

688726

RFA2
Replication factor A protein 2

2

5

Small-scale

0.584

High

721355

HOG1
Mitogen-activated protein kinase HOG1

2

10

Small-scale

0.584

High

364967

KPYK1
Pyruvate kinase 1

2

6

High-throughput

0.571

High

526120

HSP72
Heat shock protein SSA2

2

17

High-throughput

0.571

High

544086

SSB1
Ribosome-associated molecular chaperone SSB1

2

19

High-throughput

0.571

High

721351

HS104
Heat shock protein 104

2

6

High-throughput

0.571

High

721382

MPG1
Mannose-1-phosphate guanyltransferase

2

3

High-throughput

0.571

High

721385

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

2

Small-scale

0.552

High

721432

PSY3
Platinum sensitivity protein 3

1

4

Small-scale

0.552

High

721376

SSB2
Ribosome-associated molecular chaperone SSB2

2

19

High-throughput

0.552

High

721349

XPO1
Exportin-1

1

5

High-throughput

0.536

High

721354

ARP2
Actin-related protein 2

1

8

High-throughput

0.536

High

721386

MRK1
Serine/threonine-protein kinase MRK1

1

7

High-throughput

0.536

High

721431

SMT3
Ubiquitin-like protein SMT3

1

7

Small-scale

0.515

High

649208

SAN1
Protein SAN1

1

0

High-throughput

0.513

High

441062

KAPA
cAMP-dependent protein kinase type 1

1

1

High-throughput

0.501

High

517941

SSBP1
Single-stranded nucleic acid-binding protein

1

4

High-throughput

0.501

High

602357

PHO85
Cyclin-dependent protein kinase PHO85

1

10

High-throughput

0.501

High

656385

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.501

High

721357

IME2
Meiosis induction protein kinase IME2/SME1

1

15

Small-scale

0.501

High

721358

ORC2
Origin recognition complex subunit 2

1

10

Small-scale

0.501

High

721392

ATG1
Serine/threonine-protein kinase ATG1

1

4

High-throughput

0.501

High

721411

SKY1
Serine/threonine-protein kinase SKY1

1

15

High-throughput

0.501

High

721428

RTK1
Probable serine/threonine-protein kinase RTK1

1

13

High-throughput

0.501

High

721371

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

4

Small-scale

0.481

High

721380

CSM2
Chromosome segregation in meiosis protein 2

1

4

Small-scale

0.481

High

721398

IPI3
Pre-rRNA-processing protein IPI3

1

3

Small-scale

0.481

High

358145

ADH1
Alcohol dehydrogenase 1

1

3

High-throughput

0.479

High

364393

CDK1
Cyclin-dependent kinase 1

1

9

Small-scale

0.479

High

365578

PGK
Phosphoglycerate kinase

1

3

High-throughput

0.479

High

381440

H2B2
Histone H2B.2

1

20

Small-scale

0.479

High

416803

DNLI1
DNA ligase 1

1

1

Small-scale

0.479

High

434902

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

435830

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

439277

PDC1
Pyruvate decarboxylase isozyme 1

1

4

High-throughput

0.479

High

464567

PBS2
MAP kinase kinase PBS2

1

7

High-throughput

0.479

High

488594

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

2

Small-scale

0.479

High

514508

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

578995

HSC82
ATP-dependent molecular chaperone HSC82

1

12

High-throughput

0.479

High

584305

DPOD
DNA polymerase delta catalytic subunit

1

13

Small-scale

0.479

High

597405

EF3A
Elongation factor 3A

1

9

High-throughput

0.479

High

598975

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

6

High-throughput

0.479

High

638709

RIR1
Ribonucleoside-diphosphate reductase large chain 1

1

1

Small-scale

0.479

High

639545

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

1

Small-scale

0.479

High

661146

SPT6
Transcription elongation factor SPT6

1

1

Small-scale

0.479

High

682192

SPB4
ATP-dependent rRNA helicase SPB4

1

8

High-throughput

0.479

High

688840

RS5
Small ribosomal subunit protein uS7

1

3

High-throughput

0.479

High

690734

DPB3
DNA polymerase epsilon subunit C

1

1

Small-scale

0.479

High

694495

SPT5
Transcription elongation factor SPT5

1

1

Small-scale

0.479

High

706424

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

721350

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

2

Small-scale

0.479

High

721359

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

721363

SPT10
Protein SPT10

1

4

High-throughput

0.479

High

721364

DEF1
RNA polymerase II degradation factor 1

1

5

High-throughput

0.479

High

721365

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

721366

CENPA
Histone H3-like centromeric protein CSE4

1

20

High-throughput

0.479

High

721368

DPOA2
DNA polymerase alpha subunit B

1

2

Small-scale

0.479

High

721370

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

9

Small-scale

0.479

High

721372

POP2
Poly(A) ribonuclease POP2

1

1

Small-scale

0.479

High

721373

DUN1
DNA damage response protein kinase DUN1

1

12

Small-scale

0.479

High

721374

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

721377

RFC4
Replication factor C subunit 4

1

2

Small-scale

0.479

High

721378

ATAD2
ATPase histone chaperone YTA7

1

6

High-throughput

0.479

High

721381

DSN1
Kinetochore-associated protein DSN1

1

3

High-throughput

0.479

High

721384

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

721390

UFD1
Ubiquitin fusion degradation protein 1

1

4

Small-scale

0.479

High

721395

HST2
NAD-dependent protein deacetylase HST2

1

14

High-throughput

0.479

High

721404

SEN1
Helicase SEN1

1

3

Small-scale

0.479

High

721406

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

721407

MLP1
Protein MLP1

1

19

High-throughput

0.479

High

721412

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

721413

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

721414

CAB5
Dephospho-CoA kinase CAB5

1

1

High-throughput

0.479

High

721418

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

4

High-throughput

0.479

High

721419

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

721424

DIA2
Protein DIA2

1

4

Small-scale

0.479

High

721427

MLH3
DNA mismatch repair protein MLH3

1

2

High-throughput

0.479

High

721430

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

721433

DBP10
ATP-dependent RNA helicase DBP10

1

13

High-throughput

0.479

High

721435

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.479

High

721437

CMR1
DNA damage-binding protein CMR1

1

9

High-throughput

0.479

High

438128

NOT2
General negative regulator of transcription subunit 2

1

0

Small-scale

0.458

High

438265

NOT3
General negative regulator of transcription subunit 3

1

0

Small-scale

0.458

High

632840

PRI2
DNA primase large subunit

1

0

Small-scale

0.458

High

676828

DCC1
Sister chromatid cohesion protein DCC1

1

0

Small-scale

0.458

High

678932

NOT1
General negative regulator of transcription subunit 1

1

0

Small-scale

0.458

High

688782

RFA3
Replication factor A protein 3

1

0

Small-scale

0.458

High

721394

CF130
Protein CAF130

1

0

Small-scale

0.458

High

721396

CAF40
Protein CAF40

1

0

Small-scale

0.458

High

721409

ESP1
Separin

1

0

High-throughput

0.458

High

721422

RBX1
RING-box protein HRT1

1

0

Small-scale

0.458

High

721423

SGO1
Shugoshin

1

0

High-throughput

0.458

High

721425

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

386611

TBB
Tubulin beta chain

1

15

High-throughput

0.445

High

394321

EF1A
Elongation factor 1-alpha

1

6

High-throughput

0.445

High

453465

PYR1
Multifunctional protein URA2

1

5

High-throughput

0.445

High

486073

TBA1
Tubulin alpha-1 chain

1

11

High-throughput

0.445

High

592074

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.445

High

675785

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

721361

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.445

High

721375

HSP7E
Heat shock protein SSC3, mitochondrial

1

15

High-throughput

0.445

High

721388

SKP1
Suppressor of kinetochore protein 1

1

1

High-throughput

0.445

High

721399

PFD4
Prefoldin subunit 4

1

1

High-throughput

0.445

High

721415

RPN9
26S proteasome regulatory subunit RPN9

1

1

High-throughput

0.445

High

367921

ENO2
Enolase 2

1

6

High-throughput

0.437

High

368618

PMG1
Phosphoglycerate mutase 1

1

4

High-throughput

0.437

High

504088

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

721360

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.437

High

721367

CAF4
CCR4-associated factor 4

1

9

Small-scale

0.437

High

721403

NUM1
Nuclear migration protein NUM1

1

15

High-throughput

0.437

High

721426

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

721389

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.426

High

721408

RL21A
Large ribosomal subunit protein eL21A

1

0

High-throughput

0.249

Low

721421

CRT10
Protein CRT10

1

0

Small-scale

0.249

Low

721434

PNS1
Protein PNS1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025