HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: STAM1 (Q92783)
Signal transducing adapter molecule 1 (STAM-1)
Gene: STAM

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 540
+	Hs
		277010 EPHA2_HUMAN (1-976): 0: 1141: 100.00		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Hs
		872470 EPHA5_HUMAN (11-976): 0: 1127: 51.34		STAM1_HUMAN (1-518): 1.32e-126: 382: 100.00
+	Hs
		277067 EPHA7_HUMAN (4-974): 0: 1128: 50.30		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Hs
		277036 EPHA5_HUMAN (11-976): 0: 1127: 51.34		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Hs
		277037 EPHA4_HUMAN (1-976): 0: 1121: 50.25		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Hs
		277011 EPHA3_HUMAN (24-976): 0: 1111: 51.19		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Hs
		872497 EPHA5_HUMAN (11-976): 0: 1127: 51.34		GGA3_HUMAN (1-530): 3.3e-63: 221: 15.64
+	Hs
		665436 EPHA3_HUMAN (24-976): 0: 1111: 51.19		GGA3_HUMAN (1-530): 3.3e-63: 221: 15.64
+	Hs
		159897 EPHA2_HUMAN (1-976): 0: 1141: 100.00		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		665200 EPHA2_HUMAN (1-976): 0: 1141: 100.00		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		160004 EPHA7_HUMAN (4-974): 0: 1128: 50.30		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		159937 EPHA5_HUMAN (11-976): 0: 1127: 51.34		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		159938 EPHA4_HUMAN (1-976): 0: 1121: 50.25		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		924590 EPHA7_HUMAN (4-974): 0: 1128: 50.30		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		872422 EPHA5_HUMAN (11-976): 0: 1127: 51.34		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		872630 EPHA4_HUMAN (1-976): 0: 1121: 50.25		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		159898 EPHA3_HUMAN (24-976): 0: 1111: 51.19		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		665389 EPHA3_HUMAN (24-976): 0: 1111: 51.19		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		872610 EPHB1_HUMAN (27-973): 0: 1106: 47.26		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Mm
		872621 EPHB2_MOUSE (28-973): 0: 1089: 48.19		GRB2_MOUSE (215-265): 2.65e-13: 71.2: 54.90