Protein: ERAP1
Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator)

Gene: ERAP1
Organism: Homo sapiens
Interactions: 73
UniProt ID: Q9NZ08

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0002250 - adaptive immune response
GO:0002474 - antigen processing and presentation of peptide antigen via MHC class I
GO:0004175 - endopeptidase activity
GO:0004177 - aminopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1147866

DHC24
Delta(24)-sterol reductase

4

0

High-throughput

0.661

High

1251072

SG1D4
Secretoglobin family 1D member 4

2

3

High-throughput

0.628

High

1333785

TM87A
Transmembrane protein 87A

2

1

High-throughput

0.628

High

1381402

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

3

High-throughput

0.628

High

1452936

KLK11
Kallikrein-11

2

1

High-throughput

0.611

High

622696

TNR1A
Tumor necrosis factor receptor superfamily member 1A

3

0

Small-scale

0.609

High

948024

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

1410681

APOL2
Apolipoprotein L2

2

0

High-throughput

0.602

High

638540

FPR1
fMet-Leu-Phe receptor

2

6

High-throughput

0.601

High

380171

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

3

High-throughput

0.552

High

1101686

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

6

High-throughput

0.549

High

182811

GP182
G-protein coupled receptor 182

1

8

High-throughput

0.536

High

564461

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.536

High

771255

APJ
Apelin receptor

1

4

High-throughput

0.536

High

799530

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.536

High

854591

S15A1
Solute carrier family 15 member 1

1

1

High-throughput

0.536

High

957030

CXCR4
C-X-C chemokine receptor type 4

1

6

High-throughput

0.536

High

1325937

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

1

High-throughput

0.536

High

1363242

AQP3
Aquaporin-3

1

1

High-throughput

0.536

High

1452938

ALK
ALK tyrosine kinase receptor

1

4

High-throughput

0.536

High

106751

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

1006954

KC1G2
Casein kinase I isoform gamma-2

1

3

High-throughput

0.515

High

1452939

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

2

High-throughput

0.515

High

377756

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.513

High

471565

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

1186866

KR196
Keratin-associated protein 19-6

1

0

High-throughput

0.513

High

1123612

ZMYM3
Zinc finger MYM-type protein 3

1

0

High-throughput

0.493

High

1248362

TM205
Transmembrane protein 205

1

0

High-throughput

0.493

High

907068

CCR6
C-C chemokine receptor type 6

1

3

High-throughput

0.489

High

1353732

MOT10
Monocarboxylate transporter 10

1

4

High-throughput

0.489

High

1452940

GPR45
Probable G-protein coupled receptor 45

1

4

High-throughput

0.489

High

1009902

NUCB2
Nucleobindin-2

1

0

Small-scale

0.484

High

218868

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

243144

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

431471

DQB2
HLA class II histocompatibility antigen, DQ beta 2 chain

1

8

High-throughput

0.479

High

458498

ADRB2
Beta-2 adrenergic receptor

1

3

Small-scale

0.479

High

538022

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

566857

PDIA4
Protein disulfide-isomerase A4

1

3

High-throughput

0.479

High

696704

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

794648

RBMX
RNA-binding motif protein, X chromosome

1

1

Small-scale

0.479

High

850909

KI2S2
Killer cell immunoglobulin-like receptor 2DS2

1

1

High-throughput

0.479

High

891832

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.479

High

951476

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

1101317

SLAF1
Signaling lymphocytic activation molecule

1

1

High-throughput

0.479

High

1114482

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1115103

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

1252263

SYNE3
Nesprin-3

1

2

High-throughput

0.479

High

1255850

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1383122

LRC59
Leucine-rich repeat-containing protein 59

1

5

High-throughput

0.479

High

1420145

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

2

Small-scale

0.479

High

1434078

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1437644

SIAE
Sialate O-acetylesterase

1

1

High-throughput

0.479

High

1448288

FBX6
F-box only protein 6

1

6

High-throughput

0.479

High

1452935

HDAC6
Protein deacetylase HDAC6

1

2

Small-scale

0.479

High

1452937

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

477114

IL6RA
Interleukin-6 receptor subunit alpha

1

0

Small-scale

0.458

High

613206

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

1385237

PLD4
5'-3' exonuclease PLD4

1

0

High-throughput

0.458

High

1452941

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

0

Small-scale

0.458

High

538817

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

3

High-throughput

0.445

High

1227589

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.445

High

1243671

S27A1
Long-chain fatty acid transport protein 1

1

3

High-throughput

0.445

High

1449278

S22AB
Solute carrier family 22 member 11

1

5

High-throughput

0.445

High

1291913

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

7

High-throughput

0.437

High

1449978

T106B
Transmembrane protein 106B

1

1

High-throughput

0.437

High

128588

AGRP
Agouti-related protein

1

0

High-throughput

0.426

High

604753

UBF1
Nucleolar transcription factor 1

1

1

High-throughput

0.407

High

914492

EFNB2
Ephrin-B2

1

1

High-throughput

0.407

High

1162061

H31T
Histone H3.1t

1

0

Small-scale

0.391

High

952423

ROMO1
Reactive oxygen species modulator 1

2

0

High-throughput

0.319

High

1399635

OPALI
Opalin

2

0

High-throughput

0.313

High

1434803

F124B
Protein FAM124B

1

0

High-throughput

0.279

Low

1347999

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025