HitPredict

Interactor 1: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Interactor 2: KI3L1 (P43629)
Killer cell immunoglobulin-like receptor 3DL1 (CD158 antigen-like family member E) (HLA-BW4-specific inhibitory NK cell receptor) (Natural killer-associated transcript 3) (NKAT-3) (p70 natural killer cell receptor clones CL-2/CL-11) (p70 NK receptor CL-2/CL-11) (CD antigen CD158e)
Gene: KIR3DL1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15187115
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042267 - natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 444
+	Hs
		601466 PTN6_HUMAN (1-595): 0: 628: 100.00		FGFR2_HUMAN (2-391): 9.5e-60: 210: 13.89
+	Hs
		665922 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB1_HUMAN (1-427): 1.83e-57: 202: 29.13
+	Hs
		252776 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB3_HUMAN (1-341): 7.95e-57: 199: 31.23
+	Hs
		665916 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB2_HUMAN (1-444): 6.31e-57: 199: 29.94
+	Hs
		665921 PTN6_HUMAN (1-595): 0: 628: 100.00		LIRB4_HUMAN (1-237): 4.06e-52: 183: 32.92
+	Mm
		665991 PTN6_MOUSE (1-595): 0: 611: 94.45		LRB4A_MOUSE (1-233): 4.98e-58: 195: 27.85
+	Hs
		665820 PTN6_HUMAN (1-595): 0: 628: 100.00		KI2L3_HUMAN (1-241): 1.92e-42: 154: 38.82
+	Hs
		665819 PTN6_HUMAN (1-595): 0: 628: 100.00		KI2L1_HUMAN (1-233): 1.07e-40: 150: 39.17
+	Mm
		665982 PTN6_MOUSE (1-595): 0: 611: 94.45		LIRB3_MOUSE (21-424): 3.22e-39: 152: 23.98
+	Hs
		665941 PTN6_HUMAN (1-595): 0: 628: 100.00		FCRL3_HUMAN (21-341): 3.62e-27: 116: 18.26
+	Hs
		532361 PTN6_HUMAN (1-595): 0: 628: 100.00		CEAM1_HUMAN (16-231): 4.6e-24: 106: 16.13
+	Mm
		665992 PTN6_MOUSE (1-595): 0: 611: 94.45		FCRL5_MOUSE (5-343): 4.11e-24: 106: 16.43
+	Hs
		665902 PTN6_HUMAN (1-595): 0: 628: 100.00		LAIR1_HUMAN (119-224): 1.88e-15: 78.5: 27.27
+	Mm
		665995 PTN6_MOUSE (1-595): 0: 611: 94.45		LAIR1_MOUSE (224-431): 3.35e-14: 74.3: 22.18
+	Hs
		601515 PTPRR_HUMAN (5-515): 1.13e-123: 381: 24.86		FGFR2_HUMAN (2-391): 9.5e-60: 210: 13.89
+	Hs
		616999 PTPRD_HUMAN (126-516): 3.18e-114: 376: 29.41		LIRB4_HUMAN (1-237): 4.06e-52: 183: 32.92
+	Hs
		616953 PTPRD_HUMAN (126-516): 3.18e-114: 376: 29.41		KI2L1_HUMAN (1-233): 1.07e-40: 150: 39.17
+	Mm
		682309 PTN12_MOUSE (218-575): 3.21e-115: 362: 32.42		CEAM1_MOUSE (29-342): 1.43e-34: 136: 15.18
+	Hs
		1069932 PTPRK_HUMAN (72-519): 3.22e-71: 251: 21.06		LRIG3_HUMAN (25-387): 3.7e-55: 199: 14.40
+	Hs
		1069952 PTPRK_HUMAN (72-519): 3.22e-71: 251: 21.06		PXDN_HUMAN (16-125): 6.96e-15: 79.2: 20.00