HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: NEB2 (Q96SB3)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: PPP1R9B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ~PID
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 817
+	Hs
		1287792 Q96D37_HUMAN (163-578): 1.11e-54: 200: 12.25		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Hs
		548744 VAV_HUMAN (163-578): 1.81e-54: 200: 12.25		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Hs
		924806 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Dm
		113386 Q9VCM6_DROME (67-319): 2.37e-39: 156: 18.42		M9NFI9_DROME (255-816): 1.29e-53: 204: 33.63
+	Hs
		557729 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		RIMS1_HUMAN (126-637): 9e-45: 177: 17.41
+	Hs
		1115807 Q49AR9_HUMAN (40-425): 1.96e-47: 176: 18.14		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Hs
		1252371 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Hs
		209122 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Mm
		1143409 Q8BZM2_MOUSE (39-364): 4.48e-49: 178: 17.86		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Mm
		1143393 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Hs
		209019 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		AFAD_HUMAN (411-642): 8.91e-29: 126: 27.69
+	Mm
		887083 ANS1A_MOUSE (40-393): 8.46e-43: 166: 16.85		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Hs
		876392 SHB_HUMAN (369-579): 2.01e-41: 158: 20.63		AFAD_HUMAN (411-642): 8.91e-29: 126: 27.69
+	Mm
		223014 NCK2_MOUSE (363-579): 1.02e-42: 159: 18.83		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Hs
		924673 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		RIMS1_HUMAN (126-637): 9e-45: 177: 17.41
+	Hs
		655344 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		DLG1_HUMAN (435-691): 6e-19: 94.1: 15.04
+	Hs
		924718 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Hs
		129286 P85B_HUMAN (358-581): 2.69e-29: 125: 17.47		DLG1_HUMAN (435-691): 6e-19: 94.1: 15.04
+	Hs
		876349 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		AFAD_HUMAN (411-642): 8.91e-29: 126: 27.69
+	Hs
		924466 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		DLG4_HUMAN (438-714): 5.19e-28: 122: 16.38