HitPredict

Interactor 1: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: NGAP (Q9UJF2)
Ras GTPase-activating protein nGAP (RAS protein activator-like 2)
Gene: RASAL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C2~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 583 Hs			1 1139
+	Hs
		1191813 ANS1B_HUMAN (39-351): 1.55e-45: 175: 17.96		NGAP_HUMAN (1-1139): 0: 1051: 100.00
+	Hs
		1115792 Q49AR9_HUMAN (40-425): 1.96e-47: 176: 18.14		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Hs
		1139204 ANS1B_HUMAN (39-351): 1.55e-45: 175: 17.96		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Hs
		1139206 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Hs
		655393 P85A_HUMAN (300-581): 2.38e-38: 152: 15.31		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Hs
		666039 SHC1_HUMAN (1-583): 0: 531: 100.00		IQGA1_HUMAN (88-751): 2.04e-132: 443: 12.10
+	Mm
		957246 SHC1_MOUSE (1-583): 0: 527: 94.51		IQGA1_MOUSE (126-751): 1.8e-133: 446: 12.33
+	Mm
		100037 ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86		SYGP1_MOUSE (2-1138): 0: 768: 43.44
+	Hs
		1299777 GULP1_HUMAN (137-418): 7.16e-48: 171: 19.79		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Hs
		1268491 ANS1A_HUMAN (40-393): 2.28e-42: 165: 18.41		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Hs
		209146 NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Rn
		78203 SHC1_RAT (111-583): 1.45e-142: 422: 94.72		B5DFH1_RAT (126-751): 1.82e-138: 445: 12.33
+	Hs
		442777 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		RASA1_HUMAN (91-623): 3.64e-142: 457: 26.50
+	Hs
		557601 NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30		RASA1_HUMAN (91-623): 3.64e-142: 457: 26.50
+	Hs
		809221 BMX_HUMAN (341-582): 1.11e-38: 153: 19.69		IQGA1_HUMAN (88-751): 2.04e-132: 443: 12.10
+	Hs
		129241 P85B_HUMAN (358-581): 2.69e-29: 125: 17.47		IQGA1_HUMAN (88-751): 2.04e-132: 443: 12.10
+	Hs
		442830 HCK_HUMAN (348-575): 2.72e-43: 164: 17.16		RASA3_HUMAN (169-570): 2.21e-123: 401: 25.97
+	Hs
		596390 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		RASA1_HUMAN (91-623): 3.64e-142: 457: 26.50
+	Hs
		809254 GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48		IQGA1_HUMAN (88-751): 2.04e-132: 443: 12.10
+	Hs
		310885 SH23A_HUMAN (475-581): 3.64e-17: 86.8: 33.06		RASL1_HUMAN (171-558): 9.51e-110: 363: 25.41