Protein: SEC4
Ras-related protein SEC4 (Suppressor of RHO3 protein 6)

Gene: SEC4
Organism: Saccharomyces cerevisiae S288C
Interactions: 102
UniProt ID: P07560

Gene Ontology (top 5):
GO:0000131 - incipient cellular bud site
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

458527

SEC2
Rab guanine nucleotide exchange factor SEC2

11

5

Small-scale

0.979

High

458569

GDI1
Rab GDP-dissociation inhibitor

9

20

Small-scale

0.970

High

458528

MYO2
Myosin-2

6

10

Small-scale

0.956

High

458546

MSS4
Protein DSS4

4

1

Small-scale

0.913

High

458586

GYP3
GTPase-activating protein GYP3

3

19

Small-scale

0.845

High

458549

RAEP
Rab proteins geranylgeranyltransferase component A

4

20

Small-scale

0.794

High

376255

YPT1
GTP-binding protein YPT1

2

18

High-throughput

0.789

High

458594

GYP2
GTPase-activating protein GYP2

2

18

Small-scale

0.778

High

458612

GYP1
GTPase-activating protein GYP1

2

19

Small-scale

0.778

High

458533

SEC15
Exocyst complex component SEC15

5

4

Small-scale

0.719

High

458613

SRO7
Lethal(2) giant larvae protein homolog SRO7

4

1

Small-scale

0.705

High

458545

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

5

Small-scale

0.647

High

458616

MSB4
GTPase-activating protein MSB4

1

20

Small-scale

0.647

High

458598

YIF1
Protein transport protein YIF1

2

4

Small-scale

0.633

High

458558

BOI1
BEM1-interacting protein 1

1

6

Small-scale

0.621

High

458570

BOI2
BEM1-interacting protein 2

1

5

Small-scale

0.621

High

458532

VPS15
Serine/threonine-protein kinase VPS15

1

5

High-throughput

0.618

High

458535

VPS34
Phosphatidylinositol 3-kinase VPS34

1

11

High-throughput

0.618

High

458552

SEC3
Exocyst complex component SEC3

1

9

Small-scale

0.618

High

458563

RGD1
RHO GTPase-activating protein RGD1

1

1

Small-scale

0.618

High

458591

ATG1
Serine/threonine-protein kinase ATG1

1

7

High-throughput

0.618

High

458525

HSC82
ATP-dependent molecular chaperone HSC82

2

7

High-throughput

0.584

High

458560

ATG8
Autophagy-related protein 8

2

7

High-throughput

0.584

High

458578

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

458596

MSO1
Protein MSO1

2

0

Small-scale

0.581

High

458597

PRA1
Prenylated Rab acceptor 1

1

12

Small-scale

0.573

High

458573

SEC9
Protein transport protein SEC9

2

0

Small-scale

0.561

High

458530

RAD53
Serine/threonine-protein kinase RAD53

1

4

High-throughput

0.553

High

458536

SIS1
Protein SIS1

1

3

High-throughput

0.553

High

458601

CDC14
Tyrosine-protein phosphatase CDC14

1

3

Small-scale

0.552

High

458619

LAS17
Proline-rich protein LAS17

1

5

Small-scale

0.549

High

458577

GYP8
GTPase-activating protein GYP8

1

0

Small-scale

0.541

High

458543

HXT1
Low-affinity glucose transporter HXT1

1

3

High-throughput

0.541

High

458600

ALO
D-arabinono-1,4-lactone oxidase

1

1

High-throughput

0.541

High

458606

GYL1
Probable GTPase-activating protein GYL1

1

14

High-throughput

0.541

High

458547

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

0

Small-scale

0.529

High

458590

YIP4
Protein YIP4

1

7

Small-scale

0.523

High

458620

PEX11
Peroxisomal membrane protein PMP27

1

0

High-throughput

0.518

High

458529

EXO70
Exocyst complex component EXO70

1

1

Small-scale

0.501

High

458548

SEC8
Exocyst complex component SEC8

1

2

Small-scale

0.501

High

458561

EXO84
Exocyst complex component EXO84

1

1

Small-scale

0.501

High

458589

YIP1
Protein transport protein YIP1

1

7

Small-scale

0.481

High

392029

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

458524

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

3

Small-scale

0.479

High

458526

SEC23
Protein transport protein SEC23

1

4

High-throughput

0.479

High

458531

TRX1
Thioredoxin-1

1

3

High-throughput

0.479

High

458537

CDC48
Cell division control protein 48

1

4

High-throughput

0.479

High

458540

SNC1
Synaptobrevin homolog 1

1

13

Small-scale

0.479

High

458542

SMY1
Kinesin-related protein SMY1

1

7

Small-scale

0.479

High

458553

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.479

High

458554

GCN1
eIF-2-alpha kinase activator GCN1

1

5

Small-scale

0.479

High

458555

KES1
Oxysterol-binding protein homolog 4

1

4

Small-scale

0.479

High

458562

ATG14
Autophagy-related protein 14

1

1

High-throughput

0.479

High

458564

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

458567

LAA1
AP-1 accessory protein LAA1

1

4

High-throughput

0.479

High

458568

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

458574

SEC24
Protein transport protein SEC24

1

4

High-throughput

0.479

High

458579

ATG18
Autophagy-related protein 18

1

5

High-throughput

0.479

High

458581

SFT1
Protein transport protein SFT1

1

1

High-throughput

0.479

High

458582

ATG27
Autophagy-related protein 27

1

1

High-throughput

0.479

High

458587

TOM22
Mitochondrial import receptor subunit TOM22

1

1

High-throughput

0.479

High

458593

MLC1
Myosin light chain 1

1

2

Small-scale

0.479

High

458603

BECN1
Vacuolar protein sorting-associated protein 30

1

1

High-throughput

0.479

High

458607

SEC13
Protein transport protein SEC13

1

5

High-throughput

0.479

High

458615

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.479

High

458566

YM11
Uncharacterized protein YMR124W

1

0

Small-scale

0.460

High

458575

BUD6
Bud site selection protein 6

1

0

Small-scale

0.460

High

458605

VPS16
Vacuolar protein sorting-associated protein 16

1

0

Small-scale

0.460

High

382787

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

458534

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

458538

SPT5
Transcription elongation factor SPT5

1

0

Small-scale

0.458

High

458557

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

458576

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

458588

SC6B1
Protein transport protein SBH1

1

0

Small-scale

0.458

High

458618

YOP1
Protein YOP1

1

0

Small-scale

0.458

High

458523

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

458572

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

458602

SED5
Integral membrane protein SED5

1

14

Small-scale

0.445

High

458611

TLG2
t-SNARE affecting a late Golgi compartment protein 2

1

12

Small-scale

0.445

High

458539

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

458541

HS104
Heat shock protein 104

1

4

High-throughput

0.437

High

458544

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.437

High

458550

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

458551

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.437

High

458559

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

458599

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.437

High

458604

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.437

High

458608

IVY1
Protein IVY1

1

1

Small-scale

0.437

High

458609

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

458610

ATG23
Autophagy-related protein 23

1

1

High-throughput

0.437

High

458621

CMR1
DNA damage-binding protein CMR1

1

5

High-throughput

0.437

High

458556

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.426

High

458592

YIP5
Protein YIP5

1

1

Small-scale

0.417

High

458580

IRC6
Increased recombination centers protein 6

1

0

Small-scale

0.292

High

458565

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

458571

PXP1
2-hydroxyacyl-CoA lyase

1

0

High-throughput

0.249

Low

458583

NET1
Nucleolar protein NET1

1

0

Small-scale

0.249

Low

458584

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

458585

BPL1
Biotin--protein ligase

1

0

Small-scale

0.249

Low

458595

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

458614

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.249

Low

458617

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025