HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: CTBP1 (Q13363)
C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)
Gene: CTBP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.754

Property	Details
Experiments	26186194, 28514442, 33961781, 35016035, 15525529, 26496610, 16510875, 31041561
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008285 - negative regulation of cell population proliferation
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2843 Hs			1 440
+	Dm
		234524 Q9Y1T2_DROME (327-1450): 1.9e-166: 547: 26.33		CTBP_DROME (1-361): 1.46e-143: 420: 70.91
+	Hs
		1103168 MDC1_HUMAN (1994-2830): 2.42e-23: 111: 11.16		CTBP1_HUMAN (1-440): 0: 552: 100.00
+	Hs
		1103451 SRRM2_HUMAN (710-2256): 1.43e-21: 105: 9.26		CTBP1_HUMAN (1-440): 0: 552: 100.00
+	Hs
		96935 E9PGC8_HUMAN (751-2381): 8.31e-20: 100: 8.02		CTBP1_HUMAN (1-440): 0: 552: 100.00
+	Hs
		1103484 PCLO_HUMAN (2115-2843): 6.69e-19: 97.4: 7.82		CTBP1_HUMAN (1-440): 0: 552: 100.00
+	Hs
		1103328 CIC_HUMAN (724-2287): 7.57e-13: 77: 7.66		CTBP1_HUMAN (1-440): 0: 552: 100.00
+	Hs
		875650 PRC2A_HUMAN (1590-2843): 9.07e-10: 67: 8.44		CTBP1_HUMAN (1-440): 0: 552: 100.00
+	Hs
		209629 TITIN_HUMAN (731-2590): 1.4e-32: 142: 7.93		SERA_HUMAN (29-404): 5.04e-123: 369: 29.23
+	Hs
		209562 MDC1_HUMAN (1994-2830): 2.42e-23: 111: 11.16		SERA_HUMAN (29-404): 5.04e-123: 369: 29.23