HitPredict

Interactor 1: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: H15 (P43276)
Histone H1.5 (H1 VAR.5) (H1b)
Gene: H1-5

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16627785
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Mm			1 223
+	Rn
		413197 Q6P751_RAT (3-301): 1.24e-144: 410: 43.23		H1T_RAT (1-206): 9.84e-33: 119: 50.48
+	Hs
		559328 CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56		H13_HUMAN (1-181): 1.41e-24: 98.6: 65.93
+	Rn
		88903 Q6P751_RAT (3-301): 1.24e-144: 410: 43.23		H11_RAT (1-120): 2.24e-19: 84.4: 68.85
+	Hs
		558990 CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56		H15_HUMAN (1-115): 9.34e-18: 80.5: 87.29
+	Hs
		625377 CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56		H11_HUMAN (38-181): 6.72e-16: 75.1: 63.89
+	Mm
		794656 CDK2_MOUSE (3-301): 8.13e-136: 389: 37.32		H15_MOUSE (1-202): 7.3e-24: 96.7: 100.00
+	Hs
		414717 CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24		H13_HUMAN (1-181): 1.41e-24: 98.6: 65.93
+	Hs
		515324 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		H13_HUMAN (1-181): 1.41e-24: 98.6: 65.93
+	Mm
		550489 CDK2_MOUSE (3-301): 8.13e-136: 389: 37.32		H12_MOUSE (1-115): 6.48e-15: 72.4: 82.61
+	Mm
		794643 CDK2_MOUSE (3-301): 8.13e-136: 389: 37.32		H11_MOUSE (1-121): 8.77e-15: 72: 69.11
+	Rn
		88899 CDK1_RAT (3-300): 1.07e-129: 372: 42.24		H11_RAT (1-120): 2.24e-19: 84.4: 68.85
+	Hs
		414716 CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24		H15_HUMAN (1-115): 9.34e-18: 80.5: 87.29
+	Hs
		414874 CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24		H11_HUMAN (38-181): 6.72e-16: 75.1: 63.89
+	Mm
		509461 CDK1_MOUSE (3-300): 1.05e-128: 370: 42.24		H12_MOUSE (1-115): 6.48e-15: 72.4: 82.61
+	Hs
		515403 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		H11_HUMAN (38-181): 6.72e-16: 75.1: 63.89
+	Hs
		960154 CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48		H11_HUMAN (38-181): 6.72e-16: 75.1: 63.89
+	Mm
		509472 CDK1_MOUSE (3-300): 1.05e-128: 370: 42.24		H11_MOUSE (1-121): 8.77e-15: 72: 69.11
+	Mm
		794650 CDK6_MOUSE (5-303): 4.02e-128: 369: 67.67		H11_MOUSE (1-121): 8.77e-15: 72: 69.11
+	Mm
		550487 CDK4_MOUSE (1-303): 1.36e-127: 367: 100.00		H12_MOUSE (1-115): 6.48e-15: 72.4: 82.61
+	Mm
		673225 CDK4_MOUSE (1-303): 1.36e-127: 367: 100.00		H11_MOUSE (1-121): 8.77e-15: 72: 69.11