HitPredict

Interactor 1: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CEBPA (P53566)
CCAAT/enhancer-binding protein alpha (C/EBP alpha)
Gene: CEBPA

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	20516642, 15107404, 11867521
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0005730 - nucleolus GO:0044877 - protein-containing complex binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 303 Mm			1 359
+	Hs
		625234 CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56		CEBPA_HUMAN (1-359): 1.03e-90: 278: 92.84
+	Mm
		862806 CDK2_MOUSE (3-301): 8.13e-136: 389: 37.32		CEBPA_MOUSE (1-359): 4.26e-95: 289: 100.00
+	Mm
		509477 CDK1_MOUSE (3-300): 1.05e-128: 370: 42.24		CEBPA_MOUSE (1-359): 4.26e-95: 289: 100.00
+	Hs
		414821 CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24		CEBPA_HUMAN (1-359): 1.03e-90: 278: 92.84
+	Hs
		515375 CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72		CEBPA_HUMAN (1-359): 1.03e-90: 278: 92.84
+	Hs
		625260 CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56		CEBPG_HUMAN (223-348): 6.04e-33: 121: 31.75