Protein: UTP12
U3 small nucleolar RNA-associated protein 12 (U3 snoRNA-associated protein 12) (DOM34-interacting protein 2) (U three protein 12)

Gene: UTP12, DIP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 107
UniProt ID: Q12220

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

678486

PWP2
Periodic tryptophan protein 2

11

17

Small-scale

0.981

High

1053135

UTP13
U3 small nucleolar RNA-associated protein 13

10

19

Small-scale

0.977

High

1053537

UTP21
U3 small nucleolar RNA-associated protein 21

7

18

Small-scale

0.967

High

823410

UTP18
U3 small nucleolar RNA-associated protein 18

8

3

Small-scale

0.752

High

1055523

NOC4
Nucleolar complex protein 4

8

7

Small-scale

0.747

High

798355

ENP1
Essential nuclear protein 1

7

3

Small-scale

0.742

High

1036432

UTP6
U3 small nucleolar RNA-associated protein 6

5

2

Small-scale

0.720

High

1046091

DHR1
Probable ATP-dependent RNA helicase DHR1

5

6

Small-scale

0.702

High

817656

UTP7
U3 small nucleolar RNA-associated protein 7

4

18

High-throughput

0.697

High

918859

UTP22
U3 small nucleolar RNA-associated protein 22

4

3

High-throughput

0.697

High

923269

ESF2
Pre-rRNA-processing protein ESF2

4

3

Small-scale

0.693

High

1084630

NOP58
Nucleolar protein 58

4

11

Small-scale

0.672

High

806598

UTP9
U3 small nucleolar RNA-associated protein 9

3

2

High-throughput

0.667

High

677620

KRR1
KRR1 small subunit processome component

3

3

High-throughput

0.656

High

844663

UTP10
U3 small nucleolar RNA-associated protein 10

3

4

High-throughput

0.640

High

1045127

UTP5
U3 small nucleolar RNA-associated protein 5

1

15

High-throughput

0.618

High

1046277

UTP15
U3 small nucleolar RNA-associated protein 15

1

17

High-throughput

0.618

High

1053792

SGD1
Suppressor of glycerol defect protein 1

2

6

High-throughput

0.614

High

826230

FAF1
Protein FAF1

2

2

Small-scale

0.611

High

865194

MPP10
U3 small nucleolar RNA-associated protein MPP10

2

5

Small-scale

0.611

High

673253

RRP7
Ribosomal RNA-processing protein 7

2

2

High-throughput

0.584

High

763652

UTP20
U3 small nucleolar RNA-associated protein 20

2

2

High-throughput

0.584

High

924002

CSL4
Exosome complex component CSL4

2

4

High-throughput

0.584

High

924664

NAT10
RNA cytidine acetyltransferase

2

3

High-throughput

0.584

High

1046826

UTP14
U3 small nucleolar RNA-associated protein 14

2

5

High-throughput

0.584

High

1056498

UTP4
U3 small nucleolar RNA-associated protein 4

2

18

Small-scale

0.584

High

1065601

BMS1
Ribosome biogenesis protein BMS1

2

7

High-throughput

0.584

High

1084418

RRP6
Exosome complex exonuclease RRP6

2

6

High-throughput

0.584

High

924206

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

16

High-throughput

0.541

High

1053621

MRD1
Multiple RNA-binding domain-containing protein 1

1

8

Small-scale

0.536

High

820120

SSB2
Ribosome-associated molecular chaperone SSB2

2

15

High-throughput

0.504

High

435436

RS3
Small ribosomal subunit protein uS3

1

7

High-throughput

0.479

High

442171

RS14A
Small ribosomal subunit protein uS11A

1

6

High-throughput

0.479

High

585409

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

10

High-throughput

0.479

High

594638

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

632766

DBP4
ATP-dependent RNA helicase HCA4

1

15

High-throughput

0.479

High

647247

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

3

High-throughput

0.479

High

672982

RRP43
Exosome complex component RRP43

1

2

High-throughput

0.479

High

735230

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

747064

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

8

High-throughput

0.479

High

754356

DCA13
Protein SOF1

1

18

High-throughput

0.479

High

758427

UTP11
U3 small nucleolar RNA-associated protein 11

1

2

High-throughput

0.479

High

782120

RL1D1
Ribosome biogenesis protein UTP30

1

7

High-throughput

0.479

High

802924

DBP8
ATP-dependent RNA helicase DBP8

1

14

High-throughput

0.479

High

803970

CIC1
Proteasome-interacting protein CIC1

1

7

High-throughput

0.479

High

804768

RRP4
Exosome complex component RRP4

1

8

High-throughput

0.479

High

804976

LRP1
Exosome complex protein LRP1

1

2

High-throughput

0.479

High

808329

RRP8
25S rRNA

1

4

High-throughput

0.479

High

818362

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

2

High-throughput

0.479

High

825099

RRT14
Regulator of rDNA transcription protein 14

1

2

High-throughput

0.479

High

825576

UTP25
U3 small nucleolar RNA-associated protein 25

1

2

High-throughput

0.479

High

852627

ROK1
ATP-dependent RNA helicase ROK1

1

11

High-throughput

0.479

High

863153

RRP41
Exosome complex component SKI6

1

20

High-throughput

0.479

High

864557

MTR4
ATP-dependent RNA helicase DOB1

1

17

High-throughput

0.479

High

865435

URB2
Nucleolar pre-ribosomal-associated protein 2

1

1

High-throughput

0.479

High

871077

NOL10
Ribosome biogenesis protein ENP2

1

4

High-throughput

0.479

High

871142

MTR3
Exosome complex component MTR3

1

2

High-throughput

0.479

High

918913

RRP46
Exosome complex component RRP46

1

20

High-throughput

0.479

High

919049

PESC
Pescadillo homolog

1

2

High-throughput

0.479

High

919197

UTP8
U3 small nucleolar RNA-associated protein 8

1

2

High-throughput

0.479

High

925219

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

4

High-throughput

0.479

High

1039877

UTP17
NET1-associated nuclear protein 1

1

18

High-throughput

0.479

High

1042271

TOM1
E3 ubiquitin-protein ligase TOM1

1

15

High-throughput

0.479

High

1043317

HAS1
ATP-dependent RNA helicase HAS1

1

20

High-throughput

0.479

High

1046485

BUD22
Bud site selection protein 22

1

2

High-throughput

0.479

High

1050210

RRP5
rRNA biogenesis protein RRP5

1

9

High-throughput

0.479

High

1051176

FCF1
rRNA-processing protein FCF1

1

2

High-throughput

0.479

High

1051728

RRP45
Exosome complex component RRP45

1

15

High-throughput

0.479

High

1054557

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

3

High-throughput

0.479

High

1054911

ESF1
Pre-rRNA-processing protein ESF1

1

2

High-throughput

0.479

High

1055449

RRP9
Ribosomal RNA-processing protein 9

1

19

High-throughput

0.479

High

1056329

BFR2
Protein BFR2

1

4

High-throughput

0.479

High

1060763

CMS1
Protein CMS1

1

2

High-throughput

0.479

High

1061647

RCL1
rRNA processing protein RCL1

1

3

High-throughput

0.479

High

1061960

RRP44
Exosome complex exonuclease DIS3

1

6

High-throughput

0.479

High

1062920

RRP40
Exosome complex component RRP40

1

4

High-throughput

0.479

High

1064331

UTP16
U3 small nucleolar RNA-associated protein 16

1

2

High-throughput

0.479

High

1084163

FCF2
rRNA-processing protein FCF2

1

2

High-throughput

0.479

High

1084351

SAS10
Something about silencing protein 10

1

2

High-throughput

0.479

High

1084536

MAK21
Ribosome biogenesis protein MAK21

1

7

High-throughput

0.479

High

1084626

RRP42
Exosome complex component RRP42

1

15

High-throughput

0.479

High

1084627

DBP10
ATP-dependent RNA helicase DBP10

1

16

High-throughput

0.479

High

1084628

NOP56
Nucleolar protein 56

1

11

High-throughput

0.479

High

1084629

RRP36
rRNA biogenesis protein RRP36

1

2

High-throughput

0.479

High

1084631

RRP12
Ribosomal RNA-processing protein 12

1

4

High-throughput

0.479

High

1084632

EFG1P
rRNA-processing protein EFG1

1

2

High-throughput

0.479

High

1084634

NOP14
Nucleolar complex protein 14

1

3

High-throughput

0.479

High

1084635

PNO1
Pre-rRNA-processing protein PNO1

1

2

High-throughput

0.479

High

924778

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

419907

H2A2
Histone H2A.2

1

8

High-throughput

0.437

High

503303

RS22A
Small ribosomal subunit protein uS8A

1

6

High-throughput

0.437

High

676532

PUT3
Proline utilization trans-activator

1

1

High-throughput

0.437

High

680160

CDC48
Cell division control protein 48

1

7

High-throughput

0.437

High

708527

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

710041

BMH1
Protein BMH1

1

4

High-throughput

0.437

High

748097

SMY2
Protein SMY2

1

3

High-throughput

0.437

High

812767

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

826932

DSN1
Kinetochore-associated protein DSN1

1

3

High-throughput

0.437

High

918496

EIF2A
Eukaryotic translation initiation factor 2A

1

3

High-throughput

0.437

High

925138

APJ1
J domain-containing protein APJ1

1

14

High-throughput

0.437

High

1043935

BUL2
Ubiquitin ligase-binding protein BUL2

1

1

Small-scale

0.437

High

1051624

HRQ1
ATP-dependent helicase HRQ1

1

17

Small-scale

0.437

High

1059418

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

1064294

SGO1
Shugoshin

1

2

High-throughput

0.437

High

1084633

RS22B
Small ribosomal subunit protein uS8B

1

6

High-throughput

0.437

High

727400

HS104
Heat shock protein 104

1

3

High-throughput

0.407

High

1043961

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025