HitPredict

Interactor 1: DNJA1 (P31689)
DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2)
Gene: DNAJA1

Interactor 2: HD (P42858)
Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]
Gene: HTT

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	25959826, 12417652, 32814053
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043065 - positive regulation of apoptotic process GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 397 Hs			1 3142
+	Hs
		243325 DNJA2_HUMAN (2-395): 1.59e-148: 428: 53.55		HD_HUMAN (1-3142): 0: 5724: 100.00
+	Hs
		792047 DNJB4_HUMAN (5-349): 1.73e-125: 367: 32.77		HD_HUMAN (1-3142): 0: 5724: 100.00
+	Hs
		791852 DNJA3_HUMAN (4-387): 3.67e-116: 348: 26.93		HD_HUMAN (1-3142): 0: 5724: 100.00
+	Hs
		636264 DNJB1_HUMAN (5-347): 8.67e-117: 345: 32.59		HD_HUMAN (1-3142): 0: 5724: 100.00
+	Mm
		102947 DNJA1_MOUSE (1-397): 2.91e-170: 483: 99.50		G3X9H5_MOUSE (81-3142): 0: 5479: 91.19
+	Mm
		103275 DNJA2_MOUSE (2-395): 2.15e-147: 425: 53.55		G3X9H5_MOUSE (81-3142): 0: 5479: 91.19
+	Mm
		103276 DNJB1_MOUSE (5-347): 8.34e-116: 342: 31.76		G3X9H5_MOUSE (81-3142): 0: 5479: 91.19