Protein: PSA4
Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3)

Gene: PSA4, PSMA4
Organism: Homo sapiens
Interactions: 239
UniProt ID: P25789

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0000932 - P-body
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

681102

PSA2
Proteasome subunit alpha type-2

14

20

Small-scale

0.986

High

165263

PSA7
Proteasome subunit alpha type-7

11

19

Small-scale

0.981

High

680771

PSA1
Proteasome subunit alpha type-1

10

18

Small-scale

0.973

High

681703

PSB7
Proteasome subunit beta type-7

8

20

Small-scale

0.966

High

681610

PSA6
Proteasome subunit alpha type-6

6

19

Small-scale

0.943

High

681576

PSA5
Proteasome subunit alpha type-5

5

20

Small-scale

0.922

High

681575

PSB9
Proteasome subunit beta type-9

5

20

Small-scale

0.922

High

681577

PSB4
Proteasome subunit beta type-4

5

20

Small-scale

0.922

High

681596

PSB2
Proteasome subunit beta type-2

5

20

Small-scale

0.919

High

681251

PSA3
Proteasome subunit alpha type-3

5

20

Small-scale

0.918

High

633599

PSB1
Proteasome subunit beta type-1

4

20

Small-scale

0.903

High

681615

PRS8
26S proteasome regulatory subunit 8

4

20

High-throughput

0.893

High

681614

PRS4
26S proteasome regulatory subunit 4

3

20

High-throughput

0.870

High

681595

PSB3
Proteasome subunit beta type-3

3

20

High-throughput

0.861

High

681647

PSME4
Proteasome activator complex subunit 4

3

8

Small-scale

0.861

High

681695

PSMG2
Proteasome assembly chaperone 2

3

10

Small-scale

0.861

High

681570

PSA4
Proteasome subunit alpha type-4

3

18

Small-scale

0.857

High

681574

PSB8
Proteasome subunit beta type-8

3

20

Small-scale

0.847

High

681627

PSME1
Proteasome activator complex subunit 1

3

19

Small-scale

0.847

High

681746

POMP
Proteasome maturation protein

2

8

Small-scale

0.806

High

127881

PSD11
26S proteasome non-ATPase regulatory subunit 11

2

20

High-throughput

0.806

High

681692

PSMF1
Proteasome inhibitor PI31 subunit

2

8

High-throughput

0.789

High

681709

PSMG3
Proteasome assembly chaperone 3

2

5

High-throughput

0.789

High

681578

PSB6
Proteasome subunit beta type-6

2

20

Small-scale

0.754

High

681579

PSB5
Proteasome subunit beta type-5

2

20

Small-scale

0.754

High

681583

PRS7
26S proteasome regulatory subunit 7

2

20

High-throughput

0.754

High

681688

PSMA8
Proteasome subunit alpha-type 8

2

19

High-throughput

0.754

High

681741

PSME2
Proteasome activator complex subunit 2

2

19

Small-scale

0.754

High

681608

TERA
Transitional endoplasmic reticulum ATPase

2

10

High-throughput

0.737

High

137969

PSDE
26S proteasome non-ATPase regulatory subunit 14

5

20

Small-scale

0.702

High

337445

PSMG1
Proteasome assembly chaperone 1

1

5

High-throughput

0.691

High

681588

PRS6B
26S proteasome regulatory subunit 6B

1

20

High-throughput

0.691

High

681750

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

4

18

Small-scale

0.691

High

240796

PRKN
E3 ubiquitin-protein ligase parkin

4

18

Small-scale

0.690

High

681637

IKZF1
DNA-binding protein Ikaros

3

2

High-throughput

0.675

High

681571

IKBA
NF-kappa-B inhibitor alpha

3

5

Small-scale

0.640

High

681625

UBE3A
Ubiquitin-protein ligase E3A

3

14

Small-scale

0.640

High

681587

HD
Huntingtin

2

3

High-throughput

0.621

High

681603

ATX1
Ataxin-1

2

1

High-throughput

0.621

High

128151

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

20

High-throughput

0.618

High

610230

PRS6A
26S proteasome regulatory subunit 6A

1

20

High-throughput

0.618

High

681613

PSME3
Proteasome activator complex subunit 3

1

19

Small-scale

0.618

High

681617

PRS10
26S proteasome regulatory subunit 10B

1

20

High-throughput

0.618

High

681660

PSMG4
Proteasome assembly chaperone 4

1

4

High-throughput

0.618

High

371204

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.611

High

681635

PSMD2
26S proteasome non-ATPase regulatory subunit 2

2

20

Small-scale

0.611

High

681640

CUL1
Cullin-1

2

6

Small-scale

0.611

High

681655

HIF1A
Hypoxia-inducible factor 1-alpha

2

1

Small-scale

0.611

High

142666

TRI38
E3 ubiquitin-protein ligase TRIM38

2

4

High-throughput

0.606

High

681624

REL
Proto-oncogene c-Rel

2

4

High-throughput

0.606

High

681719

CARD9
Caspase recruitment domain-containing protein 9

2

3

High-throughput

0.606

High

681585

CCNF
Cyclin-F

2

8

High-throughput

0.601

High

259468

BRD4
Bromodomain-containing protein 4

2

5

High-throughput

0.584

High

681590

YAP1
Transcriptional coactivator YAP1

2

10

High-throughput

0.584

High

681604

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

9

Small-scale

0.584

High

681607

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

11

High-throughput

0.584

High

681735

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.580

High

681601

PLK1
Serine/threonine-protein kinase PLK1

1

14

Small-scale

0.561

High

210861

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

9

High-throughput

0.536

High

251708

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

6

High-throughput

0.536

High

507088

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.536

High

563230

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.536

High

681597

PSN1
Presenilin-1

1

3

High-throughput

0.536

High

681600

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.536

High

681619

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

18

High-throughput

0.536

High

681620

SKP1
S-phase kinase-associated protein 1

1

7

High-throughput

0.536

High

681648

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

20

High-throughput

0.536

High

681650

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

9

High-throughput

0.536

High

681708

SLX1
Structure-specific endonuclease subunit SLX1

1

4

High-throughput

0.536

High

681740

AMFR
E3 ubiquitin-protein ligase AMFR

1

9

High-throughput

0.536

High

681745

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

12

High-throughput

0.536

High

681628

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.523

High

97062

E9PMD8
Proteasome 26S subunit, ATPase 3

1

20

High-throughput

0.514

High

135502

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

323964

CSTN1
Calsyntenin-1

1

0

High-throughput

0.513

High

681673

COX15
Heme A synthase COX15

1

0

High-throughput

0.513

High

681731

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.513

High

181972

UBD
Ubiquitin D

1

20

Small-scale

0.501

High

681621

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

681674

RHOU
Rho-related GTP-binding protein RhoU

1

1

High-throughput

0.501

High

226514

TLX2
T-cell leukemia homeobox protein 2

1

1

High-throughput

0.500

High

339659

KLF8
Krueppel-like factor 8

1

14

High-throughput

0.500

High

681711

KLF16
Krueppel-like factor 16

1

14

High-throughput

0.500

High

681738

KLF15
Krueppel-like factor 15

1

14

High-throughput

0.500

High

143559

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

5

High-throughput

0.479

High

282164

MAF
Transcription factor Maf

1

5

Small-scale

0.479

High

286760

SKAP2
Src kinase-associated phosphoprotein 2

1

7

High-throughput

0.479

High

293230

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

315142

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

319415

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

324553

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

333940

SMC2
Structural maintenance of chromosomes protein 2

1

1

High-throughput

0.479

High

349806

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

362165

ABL1
Tyrosine-protein kinase ABL1

1

3

Small-scale

0.479

High

362796

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

400299

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

420370

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

3

High-throughput

0.479

High

425322

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.479

High

488405

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

18

Small-scale

0.479

High

536535

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

569001

ENOB
Beta-enolase

1

6

High-throughput

0.479

High

587955

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

607530

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

5

High-throughput

0.479

High

626078

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

8

Small-scale

0.479

High

681572

U2AF2
Splicing factor U2AF 65 kDa subunit

1

6

High-throughput

0.479

High

681573

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

681580

NOS2
Nitric oxide synthase, inducible

1

4

High-throughput

0.479

High

681581

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

681582

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

681586

MNDA
Myeloid cell nuclear differentiation antigen

1

2

High-throughput

0.479

High

681589

MAP1B
Microtubule-associated protein 1B

1

5

High-throughput

0.479

High

681591

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

681592

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

681593

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

681598

CDK7
Cyclin-dependent kinase 7

1

4

High-throughput

0.479

High

681599

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

20

High-throughput

0.479

High

681602

ATX3
Ataxin-3

1

2

High-throughput

0.479

High

681605

RD23A
UV excision repair protein RAD23 homolog A

1

20

Small-scale

0.479

High

681606

RD23B
UV excision repair protein RAD23 homolog B

1

20

High-throughput

0.479

High

681611

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

681612

ARP2
Actin-related protein 2

1

1

High-throughput

0.479

High

681616

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

681622

RELB
Transcription factor RelB

1

4

High-throughput

0.479

High

681626

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

5

High-throughput

0.479

High

681629

AHNK
Neuroblast differentiation-associated protein AHNAK

1

1

High-throughput

0.479

High

681631

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

High-throughput

0.479

High

681632

NFX1
Transcriptional repressor NF-X1

1

7

High-throughput

0.479

High

681633

RED
Protein Red

1

1

High-throughput

0.479

High

681634

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

Small-scale

0.479

High

681638

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

681639

SQSTM
Sequestosome-1

1

7

High-throughput

0.479

High

681641

PTC1
Protein patched homolog 1

1

4

Small-scale

0.479

High

681642

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

14

Small-scale

0.479

High

681644

RBM39
RNA-binding protein 39

1

4

High-throughput

0.479

High

681645

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

681649

HERC3
Probable E3 ubiquitin-protein ligase HERC3

1

7

Small-scale

0.479

High

681651

NEDD8
Ubiquitin-like protein NEDD8

1

12

Small-scale

0.479

High

681653

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

681654

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

10

High-throughput

0.479

High

681656

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.479

High

681657

LARP7
La-related protein 7

1

5

High-throughput

0.479

High

681658

MIDN
Midnolin

1

4

High-throughput

0.479

High

681659

AKIR2
Akirin-2

1

6

Small-scale

0.479

High

681663

DDI2
Protein DDI1 homolog 2

1

20

High-throughput

0.479

High

681665

ECM29
Proteasome adapter and scaffold protein ECM29

1

13

High-throughput

0.479

High

681666

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

681667

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

681668

DESI1
Desumoylating isopeptidase 1

1

5

Small-scale

0.479

High

681670

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.479

High

681671

SEML
Putative protein SEM1, isoform 2

1

2

High-throughput

0.479

High

681672

MOB3C
MOB kinase activator 3C

1

4

High-throughput

0.479

High

681675

MEPCE
7SK snRNA methylphosphate capping enzyme

1

3

High-throughput

0.479

High

681677

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

681678

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

8

High-throughput

0.479

High

681680

ZN598
E3 ubiquitin-protein ligase ZNF598

1

3

High-throughput

0.479

High

681681

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

681682

GOLI
E3 ubiquitin-protein ligase RNF130

1

16

High-throughput

0.479

High

681683

VRK3
Serine/threonine-protein kinase VRK3

1

3

High-throughput

0.479

High

681686

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

681687

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.479

High

681693

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

18

High-throughput

0.479

High

681694

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.479

High

681696

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.479

High

681698

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

681699

RITA1
RBPJ-interacting and tubulin-associated protein 1

1

4

Small-scale

0.479

High

681701

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

681704

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.479

High

681705

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

4

High-throughput

0.479

High

681706

TBX5
T-box transcription factor TBX5

1

1

High-throughput

0.479

High

681707

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

681712

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

8

Small-scale

0.479

High

681713

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

681714

BHE41
Class E basic helix-loop-helix protein 41

1

2

Small-scale

0.479

High

681715

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.479

High

681716

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

681718

SHRPN
Sharpin

1

5

Small-scale

0.479

High

681720

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

681722

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

2

High-throughput

0.479

High

681723

UNKL
Putative E3 ubiquitin-protein ligase UNKL

1

3

High-throughput

0.479

High

681724

RENT2
Regulator of nonsense transcripts 2

1

1

High-throughput

0.479

High

681725

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

3

High-throughput

0.479

High

681726

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

8

High-throughput

0.479

High

681727

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

High-throughput

0.479

High

681728

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

681729

UBQL4
Ubiquilin-4

1

20

Small-scale

0.479

High

681730

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

681733

PD1L1
Programmed cell death 1 ligand 1

1

3

Small-scale

0.479

High

681734

CHMP5
Charged multivesicular body protein 5

1

4

High-throughput

0.479

High

681736

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

681737

UBQL2
Ubiquilin-2

1

20

High-throughput

0.479

High

681739

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

3

High-throughput

0.479

High

681742

FZR1
Fizzy-related protein homolog

1

9

High-throughput

0.479

High

681743

UBQL1
Ubiquilin-1

1

20

High-throughput

0.479

High

681744

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.479

High

681748

FBX7
F-box only protein 7

1

4

High-throughput

0.479

High

681749

TRAF6
TNF receptor-associated factor 6

1

9

High-throughput

0.479

High

128787

MEN1
Menin

1

0

High-throughput

0.458

High

257344

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

571371

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.458

High

590382

GATA1
Erythroid transcription factor

1

0

High-throughput

0.458

High

681584

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

681609

HDAC4
Histone deacetylase 4

1

0

High-throughput

0.458

High

681618

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

681623

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

681630

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

681689

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

681691

ASB10
Ankyrin repeat and SOCS box protein 10

1

0

Small-scale

0.458

High

681700

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

681717

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

681721

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

429329

JUN
Transcription factor Jun

1

6

High-throughput

0.445

High

529117

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

619506

VCAM1
Vascular cell adhesion protein 1

1

4

High-throughput

0.445

High

681662

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

681664

Q5VWC4
26S proteasome non-ATPase regulatory subunit 4

1

11

High-throughput

0.445

High

352983

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

411384

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

642631

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

681636

MMRN1
Multimerin-1

1

1

High-throughput

0.437

High

681643

GRM2
Metabotropic glutamate receptor 2

1

5

High-throughput

0.437

High

681690

DDI1
Protein DDI1 homolog 1

1

20

High-throughput

0.437

High

681697

RN185
E3 ubiquitin-protein ligase RNF185

1

16

Small-scale

0.437

High

681732

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

3

High-throughput

0.437

High

681747

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

681751

INSI2
Insulin-induced gene 2 protein

1

3

High-throughput

0.437

High

681669

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.426

High

681594

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.408

High

687

A0A087WW66
26S proteasome non-ATPase regulatory subunit 1

1

20

High-throughput

0.407

High

681661

TMM31
Transmembrane protein 31

1

4

High-throughput

0.407

High

681676

NIPA1
Magnesium transporter NIPA1

1

4

High-throughput

0.407

High

681679

SO6A1
Solute carrier organic anion transporter family member 6A1

1

1

High-throughput

0.407

High

681684

CTL3
Choline transporter-like protein 3

1

11

High-throughput

0.407

High

681685

CTL5
Choline transporter-like protein 5

1

11

High-throughput

0.407

High

681702

S26A8
Testis anion transporter 1

1

4

High-throughput

0.407

High

681646

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.279

Low

681710

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

High-throughput

0.279

Low

681652

SCN9A
Sodium channel protein type 9 subunit alpha

1

0

High-throughput

0.249

Low

87337

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025