Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.974

The method score is based on:

Property Details
Experiments 28205554, 31980649, 16280327, 19203586, 11579209, 11956222, 15998322, 17554339, 7891724, 24291004
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology, enzymatic study, in-gel kinase assay, protein kinase assay, coimmunoprecipitation
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PH~PH, PH~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms GO:0001649 - osteoblast differentiation
GO:0001893 - maternal placenta development
GO:0001934 - positive regulation of protein phosphorylation
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0002042 - cell migration involved in sprouting angiogenesis
and 162 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 480
Hs

1 480
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Last updated: 15 Jul 2024