HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.710

The method score is based on:

Property	Details
Experiments	10542266, 20085797, 19074868, 21242970
Identification Methods	pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0010628 - positive regulation of gene expression and 6 others more... GO:0016567 - protein ubiquitination GO:0019899 - enzyme binding GO:0032991 - protein-containing complex GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0071356 - cellular response to tumor necrosis factor
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	480
Hs

1	1863

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024