HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: AKTS1 (Q96B36)
Proline-rich AKT1 substrate 1 (40 kDa proline-rich AKT substrate)
Gene: AKT1S1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

The method score is based on:

Property	Details
Experiments	24462114, 17386266, 34941261, 12524439
Identification Methods	affinity chromatography technology, enzymatic study, in-gel kinase assay, protein kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006469 - negative regulation of protein kinase activity GO:0030291 - protein serine/threonine kinase inhibitor activity and 1 others more... GO:0042981 - regulation of apoptotic process
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	480
Hs

1	256

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024