Protein: SP110
Sp110 nuclear body protein (Interferon-induced protein 41/75) (Speckled 110 kDa) (Transcriptional coactivator Sp110)

Gene: SP110
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q9HB58

Gene Ontology (top 5):
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1437929

SP110
Sp110 nuclear body protein

1

18

High-throughput

0.618

High

171333

MYPT1
Protein phosphatase 1 regulatory subunit 12A

2

12

High-throughput

0.611

High

625635

CSK22
Casein kinase II subunit alpha'

2

10

High-throughput

0.611

High

1388741

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

12

High-throughput

0.611

High

1420935

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

15

High-throughput

0.611

High

1437943

CHIP
E3 ubiquitin-protein ligase CHIP

2

2

High-throughput

0.611

High

1383986

ARK2N
Protein ARK2N

2

0

High-throughput

0.585

High

193867

ZSC9
Zinc finger and SCAN domain-containing protein 9

1

20

High-throughput

0.541

High

1117072

RUNX3
Runt-related transcription factor 3

1

1

High-throughput

0.541

High

1437941

NP1L2
Nucleosome assembly protein 1-like 2

1

9

High-throughput

0.541

High

187187

PPM1G
Protein phosphatase 1G

1

2

High-throughput

0.536

High

253697

IMA7
Importin subunit alpha-7

1

17

High-throughput

0.536

High

562650

RINI
Ribonuclease inhibitor

1

5

High-throughput

0.536

High

967981

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

13

High-throughput

0.536

High

995282

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.536

High

1132644

KIF22
Kinesin-like protein KIF22

1

11

High-throughput

0.536

High

1134391

IMB1
Importin subunit beta-1

1

14

High-throughput

0.536

High

1161833

ZSC26
Zinc finger and SCAN domain-containing protein 26

1

20

High-throughput

0.536

High

1390975

THOC1
THO complex subunit 1

1

1

High-throughput

0.536

High

289174

PRDM1
PR domain zinc finger protein 1

1

20

Small-scale

0.515

High

342040

CEP43
Centrosomal protein 43

1

0

High-throughput

0.513

High

405547

KITH
Thymidine kinase, cytosolic

1

2

High-throughput

0.508

High

628023

ANXA7
Annexin A7

1

6

High-throughput

0.508

High

808174

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

High-throughput

0.508

High

1152476

T22D1
TSC22 domain family protein 1

1

20

High-throughput

0.508

High

1160585

SMN
Survival motor neuron protein

1

2

High-throughput

0.508

High

1437933

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

1

High-throughput

0.508

High

170360

AURKA
Aurora kinase A

1

9

High-throughput

0.479

High

208569

PJA2
E3 ubiquitin-protein ligase Praja-2

1

2

High-throughput

0.479

High

260477

BRD4
Bromodomain-containing protein 4

1

20

High-throughput

0.479

High

288779

NPM3
Nucleoplasmin-3

1

9

High-throughput

0.479

High

332049

KAT7
Histone acetyltransferase KAT7

1

7

High-throughput

0.479

High

414652

P53
Cellular tumor antigen p53

1

13

High-throughput

0.479

High

447465

NPM
Nucleophosmin

1

9

High-throughput

0.479

High

451572

CENPB
Major centromere autoantigen B

1

4

High-throughput

0.479

High

516022

SETLP
Protein SETSIP

1

8

High-throughput

0.479

High

533972

IRF1
Interferon regulatory factor 1

1

6

Small-scale

0.479

High

584585

VAV
Proto-oncogene vav

1

4

High-throughput

0.479

High

621973

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

639825

TAF1
Transcription initiation factor TFIID subunit 1

1

20

High-throughput

0.479

High

659595

CRCM
Colorectal mutant cancer protein

1

9

High-throughput

0.479

High

853413

CBX5
Chromobox protein homolog 5

1

20

High-throughput

0.479

High

887235

CEBPA
CCAAT/enhancer-binding protein alpha

1

13

Small-scale

0.479

High

902597

RT29
Small ribosomal subunit protein mS29

1

2

High-throughput

0.479

High

980354

H4
Histone H4

1

13

High-throughput

0.479

High

1014207

CBX1
Chromobox protein homolog 1

1

20

High-throughput

0.479

High

1029386

SET
Protein SET

1

8

High-throughput

0.479

High

1040759

ENL
Protein ENL

1

20

High-throughput

0.479

High

1042927

ERCC6
DNA excision repair protein ERCC-6

1

17

High-throughput

0.479

High

1045786

TF65
Transcription factor p65

1

8

High-throughput

0.479

High

1089022

TP53B
TP53-binding protein 1

1

11

High-throughput

0.479

High

1097572

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1143539

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.479

High

1143911

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

2

High-throughput

0.479

High

1213150

BEND3
BEN domain-containing protein 3

1

3

High-throughput

0.479

High

1274052

PHF5A
PHD finger-like domain-containing protein 5A

1

1

High-throughput

0.479

High

1315924

RCOR2
REST corepressor 2

1

20

High-throughput

0.479

High

1332991

MLKL
Mixed lineage kinase domain-like protein

1

7

High-throughput

0.479

High

1339885

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

1

High-throughput

0.479

High

1347087

G45IP
Large ribosomal subunit protein mL64

1

2

High-throughput

0.479

High

1367317

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1371702

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

Small-scale

0.479

High

1390036

PTCD3
Small ribosomal subunit protein mS39

1

1

High-throughput

0.479

High

1393411

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.479

High

1394890

EAF1
ELL-associated factor 1

1

1

High-throughput

0.479

High

1395144

DCAF5
DDB1- and CUL4-associated factor 5

1

20

High-throughput

0.479

High

1403555

SETB2
Histone-lysine N-methyltransferase SETDB2

1

11

High-throughput

0.479

High

1410709

SENP7
Sentrin-specific protease 7

1

6

High-throughput

0.479

High

1415542

GNL3
Guanine nucleotide-binding protein-like 3

1

10

High-throughput

0.479

High

1419350

BACH2
Transcription regulator protein BACH2

1

20

High-throughput

0.479

High

1419376

SETD2
Histone-lysine N-methyltransferase SETD2

1

14

High-throughput

0.479

High

1419695

GTPB4
GTP-binding protein 4

1

7

High-throughput

0.479

High

1429569

LSG1
Large subunit GTPase 1 homolog

1

10

High-throughput

0.479

High

1429937

BRD8
Bromodomain-containing protein 8

1

17

High-throughput

0.479

High

1437833

CLSPN
Claspin

1

6

High-throughput

0.479

High

1437930

ELL3
RNA polymerase II elongation factor ELL3

1

1

High-throughput

0.479

High

1437934

RAD18
E3 ubiquitin-protein ligase RAD18

1

4

High-throughput

0.479

High

1437936

AFF4
AF4/FMR2 family member 4

1

19

High-throughput

0.479

High

1437938

CDC23
Cell division cycle protein 23 homolog

1

15

High-throughput

0.479

High

1437940

BRPF3
Bromodomain and PHD finger-containing protein 3

1

20

High-throughput

0.479

High

1437942

APC10
Anaphase-promoting complex subunit 10

1

9

High-throughput

0.479

High

1437945

DCAF1
DDB1- and CUL4-associated factor 1

1

19

High-throughput

0.479

High

1437946

OAS3
2'-5'-oligoadenylate synthase 3

1

2

High-throughput

0.479

High

389887

TTHY
Transthyretin

1

1

High-throughput

0.464

High

67507

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.458

High

993475

SPT4H
Transcription elongation factor SPT4

1

0

High-throughput

0.458

High

1005774

RPP38
Ribonuclease P protein subunit p38

1

0

High-throughput

0.458

High

1228329

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.458

High

1403791

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1411970

PSF3
DNA replication complex GINS protein PSF3

1

0

High-throughput

0.458

High

1437932

S40A1
Ferroportin

1

0

High-throughput

0.458

High

1437935

DCA16
DDB1- and CUL4-associated factor 16

1

0

High-throughput

0.458

High

270587

LRP4
Low-density lipoprotein receptor-related protein 4

1

4

High-throughput

0.437

High

347341

BAG2
BAG family molecular chaperone regulator 2

1

5

High-throughput

0.437

High

387897

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

3

High-throughput

0.437

High

437800

HEPS
Serine protease hepsin

1

3

High-throughput

0.437

High

540094

BCR
Breakpoint cluster region protein

1

4

High-throughput

0.437

High

937609

CAD15
Cadherin-15

1

2

High-throughput

0.437

High

1004314

3BP2
SH3 domain-binding protein 2

1

5

High-throughput

0.437

High

1059057

TRHY
Trichohyalin

1

20

High-throughput

0.437

High

1103661

PHLP
Phosducin-like protein

1

1

High-throughput

0.437

High

1135112

CUL7
Cullin-7

1

9

High-throughput

0.437

High

1214199

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.437

High

1257208

ANKS3
Ankyrin repeat and SAM domain-containing protein 3

1

11

High-throughput

0.437

High

1258813

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

8

High-throughput

0.437

High

1333080

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

10

High-throughput

0.437

High

1362054

DNS2B
Deoxyribonuclease-2-beta

1

2

High-throughput

0.437

High

1364938

AP3S1
AP-3 complex subunit sigma-1

1

5

High-throughput

0.437

High

1366670

SORL
Sortilin-related receptor

1

5

High-throughput

0.437

High

1367861

HTRA1
Serine protease HTRA1

1

1

High-throughput

0.437

High

1407278

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

3

High-throughput

0.437

High

1434484

ACTL8
Actin-like protein 8

1

7

High-throughput

0.437

High

1437931

NCK5L
Nck-associated protein 5-like

1

1

High-throughput

0.437

High

1437937

KLH21
Kelch-like protein 21

1

5

High-throughput

0.437

High

1437939

PNMA2
Paraneoplastic antigen Ma2

1

7

High-throughput

0.437

High

844276

MTHR
Methylenetetrahydrofolate reductase

2

0

High-throughput

0.318

High

622279

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.282

High

327700

UBL3
Ubiquitin-like protein 3

1

0

Small-scale

0.249

Low

569158

HRES1
Putative HTLV-1-related endogenous sequence

1

0

High-throughput

0.249

Low

881809

DHYS
Deoxyhypusine synthase

1

0

High-throughput

0.249

Low

1193589

CE022
UPF0489 protein C5orf22

1

0

High-throughput

0.249

Low

1429680

SPC1L
Speriolin-like protein

1

0

High-throughput

0.249

Low

1433827

OSBL3
Oxysterol-binding protein-related protein 3

1

0

High-throughput

0.249

Low

1437944

TN13B
Tumor necrosis factor ligand superfamily member 13B

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025