HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PH, PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0043325 - phosphatidylinositol-3,4-bisphosphate binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 480 Hs			1 779
+	Hs
		682210 AKT2_HUMAN (1-477): 0: 559: 81.21		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		566481 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		623884 KPCL_HUMAN (106-477): 7.05e-149: 442: 41.98		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		408682 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		981062 KPCT_HUMAN (89-478): 2e-145: 434: 39.39		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		568795 KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		610780 KAPCB_HUMAN (138-445): 1.1e-143: 417: 42.86		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		850712 KS6A3_HUMAN (36-455): 4.1e-103: 325: 23.01		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		784090 KPCI_HUMAN (139-474): 7.46e-101: 316: 45.53		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		681831 AKT1_HUMAN (1-480): 0: 586: 100.00		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Rn
		1144020 AKT3_RAT (1-478): 0: 545: 82.29		CAPS1_RAT (11-428): 1.59e-46: 181: 10.23
+	Hs
		566377 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		408612 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		568704 KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		969077 KPCE_HUMAN (53-474): 3.43e-146: 437: 39.77		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		568798 KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		784000 KPCI_HUMAN (139-474): 7.46e-101: 316: 45.53		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Dm
		54650 APKC_DROME (142-474): 2.58e-98: 309: 43.90		SIF2_DROME (7-634): 3.14e-45: 178: 12.50
+	Hs
		1071703 KS6A2_HUMAN (85-452): 6.82e-94: 301: 25.39		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		299245 KPCI_HUMAN (139-474): 7.46e-101: 316: 45.53		FARP2_HUMAN (5-183): 2.45e-30: 130: 21.69