HitPredict

Interactor 1: HECA2 (A8MVW5)
HEPACAM family member 2 (Mitotic kinetics regulator)
Gene: HEPACAM2

Interactor 2: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.770

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ig_3~I-set, Ig_3~ig
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 462 Hs			1 822
+	Hs
		507819 NCAM1_HUMAN (22-461): 3.28e-61: 215: 15.18		FGFR1_HUMAN (1-822): 0: 861: 100.00
+	Hs
		507857 FGFR3_HUMAN (14-437): 1.57e-59: 210: 13.78		FGFR1_HUMAN (1-822): 0: 861: 100.00
+	Hs
		508034 CEA21_HUMAN (89-237): 1.08e-42: 154: 28.86		FGFR1_HUMAN (1-822): 0: 861: 100.00
+	Hs
		601456 FGFR3_HUMAN (14-437): 1.57e-59: 210: 13.78		FGFR2_HUMAN (1-821): 0: 803: 71.21
+	Hs
		609173 FGFR3_HUMAN (14-437): 1.57e-59: 210: 13.78		FGFR3_HUMAN (6-821): 0: 730: 61.22
+	Hs
		530148 NCAM1_HUMAN (22-461): 3.28e-61: 215: 15.18		FGFR4_HUMAN (29-808): 0: 664: 55.60
+	Hs
		530151 NCAM1_HUMAN (22-461): 3.28e-61: 215: 15.18		EPHA3_HUMAN (3-775): 0: 643: 19.03
+	Hs
		609225 FGFR3_HUMAN (14-437): 1.57e-59: 210: 13.78		EPHA4_HUMAN (3-783): 0: 620: 19.44
+	Hs
		608212 ROBO1_HUMAN (3-462): 2.87e-42: 162: 13.11		FGFR4_HUMAN (29-808): 0: 664: 55.60
+	Hs
		665402 CEA21_HUMAN (89-237): 1.08e-42: 154: 28.86		EPHA3_HUMAN (3-775): 0: 643: 19.03
+	Hs
		609184 FGFR3_HUMAN (14-437): 1.57e-59: 210: 13.78		EPHA2_HUMAN (3-819): 0: 583: 18.68
+	Hs
		685227 CEAM8_HUMAN (14-366): 4.75e-62: 207: 23.10		EPHB4_HUMAN (3-777): 2.12e-180: 546: 17.74
+	Mm
		530201 NCAM1_MOUSE (22-461): 2.22e-61: 218: 14.19		NTRK2_MOUSE (111-762): 1.43e-163: 497: 23.74
+	Rn
		530224 NCAM1_RAT (22-461): 4.54e-64: 223: 14.32		Q63237_RAT (1-417): 4.39e-158: 469: 60.38
+	Hs
		384188 NCAM1_HUMAN (22-461): 3.28e-61: 215: 15.18		NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96
+	Mm
		724165 LRIG1_MOUSE (142-436): 5.16e-42: 161: 13.69		RET_MOUSE (446-774): 1.13e-101: 341: 51.59
+	Hs
		299548 LRIG2_HUMAN (142-435): 2.6e-41: 159: 18.47		RET_HUMAN (384-774): 2.63e-98: 332: 45.77
+	Hs
		725306 PSG5_HUMAN (15-338): 8.4e-65: 213: 21.78		TIE1_HUMAN (484-771): 2.11e-70: 253: 47.57
+	Mm
		530211 NCAM1_MOUSE (22-461): 2.22e-61: 218: 14.19		PTK7_MOUSE (162-433): 2.54e-17: 89: 16.36
+	Hs
		685235 CEAM8_HUMAN (14-366): 4.75e-62: 207: 23.10		PTK7_HUMAN (162-385): 7.97e-17: 87.5: 17.39