HitPredict

Interactor 1: IL2RG (P31785)
Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
Gene: IL2RG

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27742835
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010467 - gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 369 Hs			1 594
+	Hs
		872612 EPHB1_HUMAN (25-348): 1.08e-46: 172: 11.40		GRB10_HUMAN (1-594): 0: 712: 100.00
+	Hs
		500963 GHR_HUMAN (48-294): 1.74e-45: 166: 14.96		GRB10_HUMAN (1-594): 0: 712: 100.00
+	Hs
		872614 EPHB1_HUMAN (25-348): 1.08e-46: 172: 11.40		GRB7_HUMAN (107-594): 1.36e-174: 507: 55.60
+	Hs
		548629 PRLR_HUMAN (51-294): 8.34e-46: 167: 16.28		VAV_HUMAN (36-594): 3.93e-139: 426: 14.11
+	Hs
		665618 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		RAPH1_HUMAN (34-484): 6.16e-107: 350: 23.94
+	Hs
		560471 PRLR_HUMAN (51-294): 8.34e-46: 167: 16.28		VAV2_HUMAN (40-588): 1.7e-95: 313: 12.26
+	Hs
		682260 IL2RG_HUMAN (1-369): 6.04e-109: 325: 100.00		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		560468 PRLR_HUMAN (51-294): 8.34e-46: 167: 16.28		TEC_HUMAN (293-590): 2.81e-52: 191: 12.33
+	Mm
		403425 EPHB2_MOUSE (24-348): 1.41e-49: 180: 11.36		SRC_MOUSE (443-590): 1.24e-46: 173: 22.08
+	Hs
		433265 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		YES_HUMAN (441-592): 9.17e-47: 174: 20.89
+	Hs
		522803 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		SRC_HUMAN (443-590): 9.55e-47: 174: 22.08
+	Hs
		412104 EPHA5_HUMAN (43-348): 8.3e-45: 166: 12.87		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		433772 EPHA7_HUMAN (34-348): 3.58e-45: 168: 10.98		LYN_HUMAN (409-593): 7.45e-46: 171: 17.19
+	Mm
		872621 EPHB2_MOUSE (24-348): 1.41e-49: 180: 11.36		GRB2_MOUSE (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		665574 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		872610 EPHB1_HUMAN (25-348): 1.08e-46: 172: 11.40		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		924590 EPHA7_HUMAN (34-348): 3.58e-45: 168: 10.98		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		500956 GHR_HUMAN (48-294): 1.74e-45: 166: 14.96		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		872422 EPHA5_HUMAN (43-348): 8.3e-45: 166: 12.87		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		924483 IL5RA_HUMAN (14-295): 5.9e-46: 164: 18.87		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89