HitPredict

Interactor 1: CASPE (P31944)
Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
Gene: CASP14

Interactor 2: ZRAN1 (Q9UGI0)
Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1)
Gene: ZRANB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	33853758, 35944360
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 242 Hs			1 708
+	Hs
		876965 CASP7_HUMAN (7-241): 1.72e-89: 268: 26.91		ZRAN1_HUMAN (1-697): 0: 987: 100.00
+	Hs
		788233 CASP3_HUMAN (11-241): 2.94e-87: 261: 29.80		ZRAN1_HUMAN (1-697): 0: 987: 100.00
+	Hs
		1059309 CASP8_HUMAN (12-241): 7.41e-80: 249: 29.58		OTU7B_HUMAN (322-701): 2.32e-127: 400: 25.54
+	Hs
		877066 CASP6_HUMAN (8-241): 7.15e-80: 243: 28.46		OTU7B_HUMAN (322-701): 2.32e-127: 400: 25.54
+	Mm
		667125 CASP1_MOUSE (3-241): 1.01e-86: 264: 23.74		TNAP3_MOUSE (392-651): 2.36e-92: 306: 36.10
+	Hs
		599670 CASP8_HUMAN (12-241): 7.41e-80: 249: 29.58		TNAP3_HUMAN (392-651): 2.48e-93: 308: 35.74
+	Hs
		667483 CASP1_HUMAN (6-241): 3.79e-86: 262: 24.71		RNF31_HUMAN (29-410): 7.77e-78: 271: 15.73
+	Hs
		1059341 CASP8_HUMAN (12-241): 7.41e-80: 249: 29.58		RNF31_HUMAN (29-410): 7.77e-78: 271: 15.73
+	Hs
		877118 CASP6_HUMAN (8-241): 7.15e-80: 243: 28.46		RNF31_HUMAN (29-410): 7.77e-78: 271: 15.73
+	Hs
		181632 CFLAR_HUMAN (4-241): 1.84e-67: 217: 21.69		RNF31_HUMAN (29-410): 7.77e-78: 271: 15.73