HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.50	0.593

Property	Details
Experiments	33294266, 33961781, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 499
+	Hs
		834015 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		683207 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		834018 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		625306 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		646727 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Hs
		625334 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		909447 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK3_HUMAN (160-495): 1.29e-125: 370: 24.20
+	Hs
		683268 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CDK3_HUMAN (160-495): 1.29e-125: 370: 24.20
+	Hs
		646728 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		909877 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20
+	At
		847169 14332_ARATH (1-241): 4.75e-145: 407: 63.27		AFC1_ARATH (135-486): 6.42e-116: 351: 43.05
+	Hs
		910066 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYRK4_HUMAN (128-495): 1.15e-113: 347: 29.35
+	Hs
		625130 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		910197 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYR1B_HUMAN (108-488): 2.22e-110: 342: 29.03
+	Hs
		909539 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		683331 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Mm
		910255 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		DYR1A_MOUSE (108-485): 1.95e-104: 330: 28.25
+	Hs
		646799 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		CDK3_HUMAN (160-495): 1.29e-125: 370: 24.20
+	Hs
		927021 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		646876 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50