HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: CDK16 (Q00536)
Cyclin-dependent kinase 16 (EC 2.7.11.22) (Cell division protein kinase 16) (PCTAIRE-motif protein kinase 1) (Serine/threonine-protein kinase PCTAIRE-1)
Gene: CDK16

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	32707033, 35271311, 24255178
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 496
+	Hs
		909448 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK16_HUMAN (1-496): 2.61e-178: 511: 100.00
+	Hs
		926924 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CDK16_HUMAN (1-496): 2.61e-178: 511: 100.00
+	Hs
		909449 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK17_HUMAN (4-490): 2.31e-154: 451: 68.67
+	Hs
		683270 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CDK17_HUMAN (4-490): 2.31e-154: 451: 68.67
+	Hs
		926925 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CDK17_HUMAN (4-490): 2.31e-154: 451: 68.67
+	Hs
		625306 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54
+	Hs
		909447 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06
+	Hs
		625334 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CDK2_HUMAN (162-456): 6.05e-145: 418: 53.54
+	Hs
		683268 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CDK3_HUMAN (162-453): 2.39e-142: 412: 53.06
+	Hs
		909472 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK18_HUMAN (1-490): 5.61e-137: 405: 61.84
+	Hs
		683288 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CDK18_HUMAN (1-490): 5.61e-137: 405: 61.84
+	Dm
		955007 1433E_DROME (3-245): 4.63e-144: 405: 64.90		Q7KM03_DROME (4-479): 4.35e-136: 404: 43.81
+	Dm
		955011 1433E_DROME (3-245): 4.63e-144: 405: 64.90		Q94888_DROME (4-479): 1.48e-135: 402: 44.47
+	At
		965298 14332_ARATH (1-241): 4.75e-145: 407: 63.27		MPK7_ARATH (152-490): 6.63e-132: 388: 31.79
+	Hs
		300632 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK14_HUMAN (159-474): 3.24e-130: 387: 60.19
+	Hs
		841132 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK7_HUMAN (160-481): 5.55e-132: 387: 37.69
+	Hs
		300628 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CDK14_HUMAN (159-474): 3.24e-130: 387: 60.19
+	Hs
		683213 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CDK7_HUMAN (160-481): 5.55e-132: 387: 37.69
+	Hs
		300633 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CDK14_HUMAN (159-474): 3.24e-130: 387: 60.19
+	Hs
		841150 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CDK7_HUMAN (160-481): 5.55e-132: 387: 37.69