HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: KSR2 (Q6VAB6)
Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1)
Gene: KSR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 950
+	Hs
		909702 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KSR2_HUMAN (1-950): 0: 804: 100.00
+	Mm
		910254 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		KSR1_MOUSE (17-950): 0: 576: 44.98
+	Mm
		926799 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		KSR1_MOUSE (17-950): 0: 576: 44.98
+	Hs
		909466 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RON_HUMAN (78-935): 2.46e-145: 468: 16.94
+	Hs
		683284 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RON_HUMAN (78-935): 2.46e-145: 468: 16.94
+	Hs
		909779 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KSR1_HUMAN (18-950): 4.63e-144: 453: 40.02
+	Hs
		683523 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KSR1_HUMAN (18-950): 4.63e-144: 453: 40.02
+	Hs
		46556 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		A0A2R8Y8E0_HUMAN (325-942): 7.38e-140: 439: 22.86
+	Mm
		554972 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		MET_MOUSE (88-934): 1.75e-135: 441: 13.78
+	Mm
		655938 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		BRAF_MOUSE (284-942): 7.45e-137: 429: 22.01
+	Hs
		110869 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		H7C560_HUMAN (325-942): 4.38e-135: 425: 22.19
+	Hs
		542849 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		BRAF_HUMAN (325-942): 1.44e-134: 423: 22.19
+	Mm
		655943 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		BRAF_MOUSE (284-942): 7.45e-137: 429: 22.01
+	Hs
		542827 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		BRAF_HUMAN (325-942): 1.44e-134: 423: 22.19
+	Gg
		982842 1433E_CHICK (3-243): 4.39e-144: 405: 65.43		BRAF_CHICK (324-942): 1.32e-131: 416: 22.62
+	Hs
		373995 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RAF1_HUMAN (304-945): 1.34e-129: 407: 22.49
+	Hs
		373771 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RAF1_HUMAN (304-945): 1.34e-129: 407: 22.49
+	Hs
		488645 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ARAF_HUMAN (321-949): 4.2e-127: 399: 22.12
+	Hs
		488590 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		ARAF_HUMAN (321-949): 4.2e-127: 399: 22.12
+	Dm
		507708 1433E_DROME (3-245): 4.63e-144: 405: 64.90		KRAF1_DROME (411-942): 6.95e-111: 360: 26.57