HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: RHG23 (Q9P227)
Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)
Gene: ARHGAP23

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	33961781, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1491
+	Hs
		70666 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MYO9A_HUMAN (134-1403): 5.16e-136: 468: 12.33
+	Hs
		70650 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MYO9A_HUMAN (134-1403): 5.16e-136: 468: 12.33
+	Mm
		910322 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		SRGP2_MOUSE (618-1485): 6.27e-95: 333: 15.21
+	Hs
		253335 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SRGP2_HUMAN (618-1485): 2.37e-92: 326: 15.18
+	Hs
		253321 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SRGP2_HUMAN (618-1485): 2.37e-92: 326: 15.18
+	Hs
		909743 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SRGP1_HUMAN (609-1480): 5.04e-92: 325: 15.15
+	Hs
		683497 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SRGP1_HUMAN (609-1480): 5.04e-92: 325: 15.15
+	Hs
		909659 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SYDE2_HUMAN (157-1192): 8.76e-91: 323: 14.75
+	Hs
		683426 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SYDE2_HUMAN (157-1192): 8.76e-91: 323: 14.75
+	Mm
		910285 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		SRGP3_MOUSE (609-1451): 3.43e-85: 305: 14.94
+	Hs
		64684 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RHG32_HUMAN (879-1226): 1.46e-62: 238: 21.16
+	Hs
		64662 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RHG32_HUMAN (879-1226): 1.46e-62: 238: 21.16
+	Hs
		64689 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		RHG32_HUMAN (879-1226): 1.46e-62: 238: 21.16
+	Hs
		909650 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RHG21_HUMAN (31-784): 3.88e-49: 195: 23.81
+	Hs
		683416 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		RHG21_HUMAN (31-784): 3.88e-49: 195: 23.81
+	Hs
		909637 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		Q5JSD8_HUMAN (919-1043): 2.82e-49: 172: 64.00
+	Hs
		683402 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		Q5JSD8_HUMAN (919-1043): 2.82e-49: 172: 64.00
+	Hs
		506563 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		BCR_HUMAN (915-1069): 2.76e-21: 103: 40.00
+	Hs
		506525 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		BCR_HUMAN (915-1069): 2.76e-21: 103: 40.00
+	Mm
		926818 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		BCR_MOUSE (903-1069): 5.79e-22: 105: 38.92