HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: UBP8 (P40818)
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
Gene: USP8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.657

Property	Details
Experiments	29880877, 15778465, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1118
+	Hs
		777027 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		UBP8_HUMAN (1-1118): 0: 830: 100.00
+	Hs
		777029 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		UBP8_HUMAN (1-1118): 0: 830: 100.00
+	Mm
		910281 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		UBP8_MOUSE (1-1118): 0: 785: 81.04
+	Hs
		646698 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		UBP8_HUMAN (1-1118): 0: 830: 100.00
+	Hs
		683179 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		UBP8_HUMAN (1-1118): 0: 830: 100.00
+	Hs
		777025 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		UBP8_HUMAN (1-1118): 0: 830: 100.00
+	Hs
		905373 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22
+	Hs
		910137 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08
+	Hs
		905375 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22
+	Hs
		927636 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08
+	Hs
		647384 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		UBP22_HUMAN (744-1109): 3.1e-111: 358: 27.72
+	Hs
		683244 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22
+	Hs
		259266 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70
+	Hs
		904415 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		UBP46_HUMAN (767-1109): 5.5e-107: 341: 27.22
+	Hs
		259272 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		UBP12_HUMAN (767-1110): 2.83e-106: 339: 27.70
+	Hs
		905236 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		UBP21_HUMAN (605-1111): 9.13e-98: 323: 26.08
+	Hs
		684008 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		UBP4_HUMAN (964-1106): 5.42e-33: 140: 44.06
+	Hs
		646740 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		UBP11_HUMAN (964-1106): 7.58e-34: 143: 44.90
+	Hs
		683310 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		UBP4_HUMAN (964-1106): 5.42e-33: 140: 44.06
+	Hs
		683552 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		UBP32_HUMAN (957-1042): 1.54e-14: 80.9: 42.53