Protein: CTNB1
Catenin beta-1 (Beta-catenin)

Gene: CTNB1, Ctnnb1
Organism: Mus musculus
Interactions: 121
UniProt ID: Q02248

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000165 - MAPK cascade
GO:0000209 - protein polyubiquitination
GO:0000578 - embryonic axis specification
GO:0000791 - euchromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

486820

CADH1
Cadherin-1

16

20

Small-scale

0.982

High

205258

AXIN1
Axin-1

8

7

Small-scale

0.958

High

697743

LEF1
Lymphoid enhancer-binding factor 1

6

20

Small-scale

0.940

High

1036079

Q8BNP7
Adenomatous polyposis coli protein

5

9

Small-scale

0.919

High

580362

CADH2
Cadherin-2

5

20

Small-scale

0.906

High

1036086

TF7L2
Transcription factor 7-like 2

5

20

Small-scale

0.902

High

1036093

CNBP1
Beta-catenin-interacting protein 1

2

2

Small-scale

0.828

High

312594

AXIN2
Axin-2

2

7

Small-scale

0.793

High

750524

STF1
Steroidogenic factor 1

2

9

Small-scale

0.776

High

1036047

CTNB1
Catenin beta-1

2

13

Small-scale

0.757

High

723729

CTND1
Catenin delta-1

2

16

Small-scale

0.754

High

937528

CADH5
Cadherin-5

2

20

Small-scale

0.754

High

684459

CTNA1
Catenin alpha-1

5

12

Small-scale

0.705

High

1036062

ITF2
Transcription factor 4

5

3

Small-scale

0.705

High

1036100

GSK3B
Glycogen synthase kinase-3 beta

4

12

Small-scale

0.677

High

989503

THA
Thyroid hormone receptor alpha

1

17

Small-scale

0.665

High

1036094

KC1E
Casein kinase I isoform epsilon

3

9

Small-scale

0.664

High

107063

F8VPR5
histone acetyltransferase

3

20

Small-scale

0.661

High

721463

HMGB2
High mobility group protein B2

1

16

Small-scale

0.647

High

890090

PSN1
Presenilin-1

3

2

Small-scale

0.640

High

542855

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.618

High

618512

ANDR
Androgen receptor

1

20

Small-scale

0.618

High

625744

ESR1
Estrogen receptor

1

20

Small-scale

0.618

High

827313

SOX6
Transcription factor SOX-6

1

20

Small-scale

0.618

High

872979

SOX2
Transcription factor SOX-2

1

20

Small-scale

0.618

High

1036059

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

6

Small-scale

0.618

High

1036065

SOX17
Transcription factor SOX-17

1

20

Small-scale

0.618

High

1036104

TF7L1
Transcription factor 7-like 1

1

20

Small-scale

0.618

High

1036048

TF65
Transcription factor p65

2

13

Small-scale

0.611

High

1036068

DLG4
Disks large homolog 4

2

5

High-throughput

0.611

High

1036090

DLGP1
Disks large-associated protein 1

2

1

High-throughput

0.611

High

1013562

TNIK
Traf2 and NCK-interacting protein kinase

2

3

Small-scale

0.601

High

1036091

TX1B3
Tax1-binding protein 3

1

11

Small-scale

0.586

High

108650

G3X9H5
Huntingtin

2

3

Small-scale

0.584

High

629243

PO5F1
POU domain, class 5, transcription factor 1

2

9

Small-scale

0.584

High

852338

CBP
Histone lysine acetyltransferase CREBBP

2

20

Small-scale

0.584

High

1036063

KLF4
Krueppel-like factor 4

2

13

Small-scale

0.584

High

1021468

PROP1
Homeobox protein prophet of Pit-1

1

4

Small-scale

0.578

High

686958

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

12

Small-scale

0.576

High

988880

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.575

High

1036077

RHG32
Rho GTPase-activating protein 32

1

7

Small-scale

0.573

High

59010

A2A5J5
Neuralized E3 ubiquitin protein ligase 2

2

2

Small-scale

0.570

High

705735

PTPRM
Receptor-type tyrosine-protein phosphatase mu

1

20

Small-scale

0.536

High

771465

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

4

High-throughput

0.536

High

1036049

PECA1
Platelet endothelial cell adhesion molecule

1

6

Small-scale

0.536

High

1036060

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

Small-scale

0.536

High

1036061

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

3

High-throughput

0.536

High

1036066

FXR1
RNA-binding protein FXR1

1

6

High-throughput

0.536

High

1036075

MYOME
Myomegalin

1

8

High-throughput

0.536

High

1036081

PEX5R
PEX5-related protein

1

6

High-throughput

0.536

High

1036092

TSC1
Hamartin

1

12

High-throughput

0.536

High

266983

FHL2
Four and a half LIM domains protein 2

1

5

Small-scale

0.506

High

1036050

MITF
Microphthalmia-associated transcription factor

1

6

Small-scale

0.506

High

666048

PAX3
Paired box protein Pax-3

1

3

Small-scale

0.501

High

1000541

CASP3
Caspase-3

1

2

Small-scale

0.501

High

1036101

CARM1
Histone-arginine methyltransferase CARM1

1

5

Small-scale

0.501

High

236453

AF10
Protein AF-10

1

5

Small-scale

0.500

High

1036089

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

Small-scale

0.493

High

772550

IRS1
Insulin receptor substrate 1

1

8

Small-scale

0.484

High

59108

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

19

Small-scale

0.479

High

74272

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.479

High

97418

PRRT2
Proline-rich transmembrane protein 2

1

2

High-throughput

0.479

High

104514

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

6

High-throughput

0.479

High

147773

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

High-throughput

0.479

High

205024

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

1

High-throughput

0.479

High

266772

LNX1
E3 ubiquitin-protein ligase LNX

1

20

High-throughput

0.479

High

266925

TERT
Telomerase reverse transcriptase

1

6

Small-scale

0.479

High

373679

MYC
Myc proto-oncogene protein

1

17

Small-scale

0.479

High

432078

JUN
Transcription factor Jun

1

7

Small-scale

0.479

High

655043

CXA1
Gap junction alpha-1 protein

1

7

Small-scale

0.479

High

671889

CCND1
G1/S-specific cyclin-D1

1

8

Small-scale

0.479

High

811944

ZO1
Tight junction protein 1

1

9

Small-scale

0.479

High

839126

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

6

Small-scale

0.479

High

844156

HD
Huntingtin

1

3

Small-scale

0.479

High

858182

MERL
Merlin

1

8

Small-scale

0.479

High

915286

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

2

High-throughput

0.479

High

999809

KIFA3
Kinesin-associated protein 3

1

12

Small-scale

0.479

High

1000175

MDFI
MyoD family inhibitor

1

1

Small-scale

0.479

High

1000292

ELAV1
ELAV-like protein 1

1

3

Small-scale

0.479

High

1000338

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

Small-scale

0.479

High

1021551

RGS14
Regulator of G-protein signaling 14

1

6

High-throughput

0.479

High

1029187

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

4

High-throughput

0.479

High

1036051

DACT3
Dapper homolog 3

1

3

Small-scale

0.479

High

1036052

CUL4A
Cullin-4A

1

20

Small-scale

0.479

High

1036053

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.479

High

1036054

FUBP2
Far upstream element-binding protein 2

1

7

Small-scale

0.479

High

1036055

FBW1A
F-box/WD repeat-containing protein 1A

1

18

Small-scale

0.479

High

1036056

CDKL5
Cyclin-dependent kinase-like 5

1

12

High-throughput

0.479

High

1036057

LRRF1
Leucine-rich repeat flightless-interacting protein 1

1

2

Small-scale

0.479

High

1036058

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

15

High-throughput

0.479

High

1036067

KIF3B
Kinesin-like protein KIF3B

1

4

Small-scale

0.479

High

1036069

SF01
Splicing factor 1

1

8

Small-scale

0.479

High

1036070

CDK6
Cyclin-dependent kinase 6

1

9

Small-scale

0.479

High

1036071

NEB2
Neurabin-2

1

16

High-throughput

0.479

High

1036072

SPOP
Speckle-type POZ protein

1

12

High-throughput

0.479

High

1036073

DACT2
Dapper homolog 2

1

2

Small-scale

0.479

High

1036074

FACD2
Fanconi anemia group D2 protein homolog

1

2

High-throughput

0.479

High

1036076

NANOG
Homeobox protein NANOG

1

7

Small-scale

0.479

High

1036078

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

3

High-throughput

0.479

High

1036080

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

6

High-throughput

0.479

High

1036082

RPGF2
Rap guanine nucleotide exchange factor 2

1

5

Small-scale

0.479

High

1036084

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

1036088

CNTP2
Contactin-associated protein-like 2

1

2

High-throughput

0.479

High

1036095

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.479

High

1036097

JAG1
Protein jagged-1

1

4

Small-scale

0.479

High

1036098

NUMB
Protein numb homolog

1

3

Small-scale

0.479

High

1036102

FOXO3
Forkhead box protein O3

1

11

Small-scale

0.479

High

313042

DCX
Neuronal migration protein doublecortin

1

0

Small-scale

0.458

High

378389

IFNB
Interferon beta

1

0

Small-scale

0.458

High

958745

CSN2
COP9 signalosome complex subunit 2

1

0

Small-scale

0.458

High

1036064

SC6A4
Sodium-dependent serotonin transporter

1

0

High-throughput

0.458

High

1036103

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

8

High-throughput

0.457

High

777867

FMR1
Fragile X messenger ribonucleoprotein 1

1

6

High-throughput

0.445

High

1036083

MK08
Mitogen-activated protein kinase 8

1

11

Small-scale

0.445

High

1036085

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

2

Small-scale

0.445

High

1036087

GRIP1
Glutamate receptor-interacting protein 1

1

17

Small-scale

0.445

High

1036096

SRCN1
SRC kinase signaling inhibitor 1

1

3

High-throughput

0.445

High

1036099

MK09
Mitogen-activated protein kinase 9

1

10

Small-scale

0.445

High

504799

PTPRQ
Phosphatidylinositol phosphatase PTPRQ

1

20

Small-scale

0.437

High

554289

PCP2
Purkinje cell protein 2

1

1

Small-scale

0.437

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025