HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: MARK1 (Q9P0L2)
Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)
Gene: MARK1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	15778465, 36736316
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 795
+	Mm
		910318 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK1_MOUSE (1-795): 0: 767: 94.34
+	Hs
		684157 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		647836 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Mm
		910234 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK2_MOUSE (2-795): 0: 672: 64.55
+	Hs
		909730 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		647862 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Mm
		910231 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK3_MOUSE (1-795): 0: 662: 62.87
+	Hs
		909916 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK4_HUMAN (1-795): 0: 570: 49.32
+	Mm
		910308 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK4_MOUSE (1-795): 0: 569: 49.01
+	Hs
		909567 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MELK_HUMAN (56-795): 1.01e-161: 485: 25.30
+	Hs
		684316 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK2_HUMAN (45-766): 2.35e-142: 444: 28.27
+	Hs
		684412 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK3_HUMAN (36-620): 8.16e-139: 444: 36.67
+	Hs
		684349 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SNRK_HUMAN (55-794): 1.35e-143: 442: 22.91
+	Hs
		683925 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		SIK1_HUMAN (38-677): 5.5e-142: 439: 31.42
+	Hs
		683920 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AAPK2_HUMAN (46-598): 4.07e-142: 431: 28.50
+	Hs
		684009 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AAPK1_HUMAN (34-579): 4.11e-142: 431: 28.10
+	Hs
		883214 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		SIK1_HUMAN (38-677): 5.5e-142: 439: 31.42
+	Rn
		871214 1433E_RAT (2-246): 4.41e-146: 410: 60.41		AAPK1_RAT (34-579): 1.58e-142: 433: 28.29
+	Hs
		871354 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AAPK2_HUMAN (46-598): 4.07e-142: 431: 28.50
+	Hs
		909507 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AAPK1_HUMAN (34-579): 4.11e-142: 431: 28.10