Protein: PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10 (MHC class I region proline-rich protein CAT53) (PP1-binding protein of 114 kDa) (Phosphatase 1 nuclear targeting subunit) (p99)

Gene: PP1RA, PPP1R10
Organism: Homo sapiens
Interactions: 178
UniProt ID: Q96QC0

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001111 - RNA polymerase II promoter clearance
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0004864 - protein phosphatase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1250031

WDR82
WD repeat-containing protein 82

2

5

Small-scale

0.825

High

775270

FUS
RNA-binding protein FUS

2

7

High-throughput

0.789

High

1160255

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

2

4

High-throughput

0.789

High

967929

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

11

8

Small-scale

0.760

High

786793

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

10

8

Small-scale

0.756

High

968416

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

5

8

Small-scale

0.720

High

318530

TOX4
TOX high mobility group box family member 4

4

8

Small-scale

0.699

High

478169

SNRPA
U1 small nuclear ribonucleoprotein A

1

4

High-throughput

0.691

High

1127092

RBM39
RNA-binding protein 39

1

3

High-throughput

0.691

High

1399697

RBM14
RNA-binding protein 14

1

3

High-throughput

0.691

High

1400690

RBM4B
RNA-binding protein 4B

1

5

High-throughput

0.691

High

1331464

ZFP41
Zinc finger protein 41 homolog

3

4

High-throughput

0.667

High

1400706

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

3

3

Small-scale

0.660

High

1400702

MMP26
Matrix metalloproteinase-26

2

20

High-throughput

0.628

High

655309

SFPQ
Splicing factor, proline- and glutamine-rich

1

3

High-throughput

0.618

High

889180

RBM25
RNA-binding protein 25

1

4

High-throughput

0.618

High

1083424

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

3

High-throughput

0.618

High

1100970

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.618

High

1124396

ELOA1
Elongin-A

1

4

High-throughput

0.618

High

1144443

NONO
Non-POU domain-containing octamer-binding protein

1

5

High-throughput

0.618

High

1148542

SF3B4
Splicing factor 3B subunit 4

1

3

High-throughput

0.618

High

1248068

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

1

High-throughput

0.618

High

1329086

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

3

High-throughput

0.618

High

1356394

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

2

High-throughput

0.618

High

1360450

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.618

High

1400687

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

15

Small-scale

0.618

High

1400700

WDR76
WD repeat-containing protein 76

1

2

High-throughput

0.618

High

1400704

DCA13
DDB1- and CUL4-associated factor 13

1

2

High-throughput

0.618

High

1400711

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.618

High

542169

TOP1
DNA topoisomerase 1

2

3

High-throughput

0.611

High

1400697

FNDC4
Fibronectin type III domain-containing protein 4

3

2

High-throughput

0.609

High

1336750

RB15B
Putative RNA-binding protein 15B

1

0

High-throughput

0.586

High

978671

RL23A
Large ribosomal subunit protein uL23

2

0

High-throughput

0.585

High

372896

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.584

High

589458

RFA2
Replication protein A 32 kDa subunit

2

3

High-throughput

0.584

High

696261

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

High-throughput

0.584

High

768938

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

905054

MECP2
Methyl-CpG-binding protein 2

2

3

High-throughput

0.584

High

1236117

CAN13
Calpain-13

2

3

High-throughput

0.574

High

1279019

TAFA3
Chemokine-like protein TAFA-3

2

3

High-throughput

0.574

High

1328658

KCD17
BTB/POZ domain-containing protein KCTD17

2

4

High-throughput

0.574

High

396750

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

1130398

RRP1B
Ribosomal RNA processing protein 1 homolog B

2

1

High-throughput

0.571

High

1149968

TERF2
Telomeric repeat-binding factor 2

2

0

Small-scale

0.569

High

457125

CAN1
Calpain-1 catalytic subunit

2

3

High-throughput

0.549

High

130584

SPT5H
Transcription elongation factor SPT5

1

3

High-throughput

0.536

High

244275

NUAK1
NUAK family SNF1-like kinase 1

1

1

High-throughput

0.536

High

251644

CCNT1
Cyclin-T1

1

2

High-throughput

0.536

High

325058

HEXI1
Protein HEXIM1

1

1

High-throughput

0.536

High

414445

P53
Cellular tumor antigen p53

1

4

High-throughput

0.536

High

480276

RU1C
U1 small nuclear ribonucleoprotein C

1

2

High-throughput

0.536

High

574433

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

High-throughput

0.536

High

600360

ZNF24
Zinc finger protein 24

1

2

High-throughput

0.536

High

659283

SP100
Nuclear autoantigen Sp-100

1

9

High-throughput

0.536

High

843890

HD
Huntingtin

1

1

High-throughput

0.536

High

879746

MAPK2
MAP kinase-activated protein kinase 2

1

1

High-throughput

0.536

High

1065376

SSRP1
FACT complex subunit SSRP1

1

5

High-throughput

0.536

High

1148872

PP1R7
Protein phosphatase 1 regulatory subunit 7

1

1

High-throughput

0.536

High

1163151

H2B2E
Histone H2B type 2-E

1

13

High-throughput

0.536

High

1228600

SPT2
Protein SPT2 homolog

1

1

High-throughput

0.536

High

1243848

CTR9
RNA polymerase-associated protein CTR9 homolog

1

1

High-throughput

0.536

High

1253101

DBX2
Homeobox protein DBX2

1

5

High-throughput

0.536

High

1396246

ASPP1
Apoptosis-stimulating of p53 protein 1

1

6

High-throughput

0.536

High

1092478

TIAM1
Rho guanine nucleotide exchange factor TIAM1

2

2

High-throughput

0.521

High

1213081

RHG21
Rho GTPase-activating protein 21

2

2

High-throughput

0.521

High

220001

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

974019

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.513

High

1053162

STP2
Nuclear transition protein 2

1

0

High-throughput

0.513

High

1294907

KMT5C
Histone-lysine N-methyltransferase KMT5C

1

0

High-throughput

0.513

High

422941

A4
Amyloid-beta precursor protein

1

10

High-throughput

0.501

High

508470

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

605783

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

3

Small-scale

0.501

High

965836

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

4

Small-scale

0.501

High

1013322

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

1154337

CYTM
Cystatin-M

1

2

High-throughput

0.489

High

1388083

ERLEC
Endoplasmic reticulum lectin 1

1

1

High-throughput

0.489

High

1028346

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.480

High

129348

MEN1
Menin

1

2

High-throughput

0.479

High

129791

CBX4
E3 SUMO-protein ligase CBX4

1

3

High-throughput

0.479

High

132244

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

212310

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

High-throughput

0.479

High

242648

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

252264

CCNT2
Cyclin-T2

1

2

High-throughput

0.479

High

260329

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

280789

PR40A
Pre-mRNA-processing factor 40 homolog A

1

6

High-throughput

0.479

High

323540

TRI37
E3 ubiquitin-protein ligase TRIM37

1

6

High-throughput

0.479

High

346213

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

401332

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.479

High

425603

ISG15
Ubiquitin-like protein ISG15

1

4

High-throughput

0.479

High

476780

RSSA
Small ribosomal subunit protein uS2

1

3

High-throughput

0.479

High

558345

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

634872

HXA5
Homeobox protein Hox-A5

1

1

High-throughput

0.479

High

675638

TYY1
Transcriptional repressor protein YY1

1

3

High-throughput

0.479

High

684364

DDX6
Probable ATP-dependent RNA helicase DDX6

1

2

High-throughput

0.479

High

714362

PML
Protein PML

1

3

High-throughput

0.479

High

761831

HSP74
Heat shock 70 kDa protein 4

1

3

Small-scale

0.479

High

862392

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.479

High

872003

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.479

High

877208

KC1D
Casein kinase I isoform delta

1

3

High-throughput

0.479

High

885875

KC1E
Casein kinase I isoform epsilon

1

4

High-throughput

0.479

High

897948

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

951817

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

970942

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

980171

H4
Histone H4

1

2

High-throughput

0.479

High

1004997

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1017136

H33
Histone H3.3

1

2

High-throughput

0.479

High

1024778

VIGLN
Vigilin

1

4

High-throughput

0.479

High

1088979

TP53B
TP53-binding protein 1

1

4

High-throughput

0.479

High

1109198

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

5

High-throughput

0.479

High

1155681

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1205082

FA76B
Protein FAM76B

1

1

High-throughput

0.479

High

1255140

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1276666

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1280417

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

1289551

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1313354

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

1335305

FA98A
Protein FAM98A

1

1

High-throughput

0.479

High

1338326

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

1347755

FA76A
Protein FAM76A

1

1

High-throughput

0.479

High

1359581

ATX2L
Ataxin-2-like protein

1

4

High-throughput

0.479

High

1367066

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

1380721

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.479

High

1387831

ZBT10
Zinc finger and BTB domain-containing protein 10

1

3

Small-scale

0.479

High

1400701

ANLN
Anillin

1

3

High-throughput

0.479

High

1400705

DDX56
Probable ATP-dependent RNA helicase DDX56

1

3

High-throughput

0.479

High

1400708

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1400710

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

1400713

LC7L2
Putative RNA-binding protein Luc7-like 2

1

1

High-throughput

0.479

High

217508

E41L2
Band 4.1-like protein 2

1

0

High-throughput

0.458

High

228348

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

711659

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.458

High

809795

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.458

High

935608

MFAP1
Microfibrillar-associated protein 1

1

0

High-throughput

0.458

High

992635

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

1163662

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

0

High-throughput

0.458

High

1241283

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.458

High

1271801

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1277893

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

1294105

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.458

High

1332836

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.458

High

1346894

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1400688

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1400689

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

High-throughput

0.458

High

1400692

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.458

High

1400693

NUSAP
Nucleolar and spindle-associated protein 1

1

0

High-throughput

0.458

High

1400694

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.458

High

1400699

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1400703

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1400707

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1400709

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.458

High

1400712

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

0

High-throughput

0.458

High

991402

SUMO1
Small ubiquitin-related modifier 1

1

1

Small-scale

0.445

High

1398328

CEP63
Centrosomal protein of 63 kDa

1

3

High-throughput

0.445

High

106504

APRIO
Alternative prion protein

1

10

High-throughput

0.437

High

272397

OBSL1
Obscurin-like protein 1

1

2

High-throughput

0.437

High

274910

LRP5
Low-density lipoprotein receptor-related protein 5

1

2

High-throughput

0.437

High

324309

ARHGF
Rho guanine nucleotide exchange factor 15

1

2

High-throughput

0.437

High

359715

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

1

High-throughput

0.437

High

412463

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

571503

GLU2B
Glucosidase 2 subunit beta

1

2

High-throughput

0.437

High

1124692

SRC8
Src substrate cortactin

1

4

High-throughput

0.437

High

1400696

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

3446

A0A0S2Z547
Rho guanine nucleotide exchange factor 15 isoform 1

1

2

High-throughput

0.407

High

839074

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

High-throughput

0.407

High

1400695

RSPH9
Radial spoke head protein 9 homolog

3

0

High-throughput

0.347

High

488843

FURIN
Furin

1

0

High-throughput

0.279

Low

964052

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.279

Low

1258677

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

1314294

EFC13
EF-hand calcium-binding domain-containing protein 13

1

0

High-throughput

0.279

Low

1331159

LSME1
Leucine-rich single-pass membrane protein 1

1

0

High-throughput

0.279

Low

1400714

BACE2
Beta-secretase 2

1

0

High-throughput

0.279

Low

337608

FMNL1
Formin-like protein 1

1

0

High-throughput

0.269

Low

720524

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

1235252

ANO7
Anoctamin-7

1

0

Small-scale

0.249

Low

1400691

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.249

Low

1400698

AAMDC
Mth938 domain-containing protein

1

0

High-throughput

0.249

Low

62580

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025